Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4534639..4535303 Replicon chromosome
Accession NZ_CP054129
Organism Citrobacter portucalensis strain BY9F36

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRV88_RS21640 Protein ID WP_032942116.1
Coordinates 4535001..4535303 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5A9BY49
Locus tag HRV88_RS21635 Protein ID WP_008786950.1
Coordinates 4534639..4534980 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRV88_RS21605 (HRV88_21545) 4529946..4530704 + 759 WP_003844769.1 phosphonate C-P lyase system protein PhnK -
HRV88_RS21610 (HRV88_21550) 4531022..4531708 + 687 WP_103015273.1 phosphonate C-P lyase system protein PhnL -
HRV88_RS21615 (HRV88_21555) 4531705..4532841 + 1137 WP_103015272.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
HRV88_RS21620 (HRV88_21560) 4532844..4533398 + 555 WP_008786953.1 ribose 1,5-bisphosphokinase -
HRV88_RS21625 (HRV88_21565) 4533385..4533819 + 435 WP_008786952.1 aminoalkylphosphonate N-acetyltransferase -
HRV88_RS21630 (HRV88_21570) 4533828..4534586 + 759 WP_235125792.1 phosphonate metabolism protein PhnP -
HRV88_RS21635 (HRV88_21575) 4534639..4534980 - 342 WP_008786950.1 HigA family addiction module antitoxin Antitoxin
HRV88_RS21640 (HRV88_21580) 4535001..4535303 - 303 WP_032942116.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRV88_RS21645 (HRV88_21585) 4535459..4535788 - 330 WP_003031807.1 DDRRRQL repeat protein YjdP -
HRV88_RS21650 (HRV88_21590) 4535858..4538122 - 2265 WP_235125812.1 hybrid sensor histidine kinase/response regulator -
HRV88_RS21655 (HRV88_21595) 4538237..4539760 + 1524 WP_153753885.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-98)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11860.49 Da        Isoelectric Point: 9.9581

>T158758 WP_032942116.1 NZ_CP054129:c4535303-4535001 [Citrobacter portucalensis]
MSKSLNIRNFRDTWLEDFFERATSHRKIPADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWINGKAEDVYLDPHIY

Download         Length: 303 bp

>T158758 NZ_CP069799:c2504653-2504546 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12986.83 Da        Isoelectric Point: 6.4743

>AT158758 WP_008786950.1 NZ_CP054129:c4534980-4534639 [Citrobacter portucalensis]
MKQASRKPTTVGDILQYEYLEPLDLKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRDVGAKKVA

Download         Length: 342 bp

>AT158758 NZ_CP069799:2504469-2504529 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5A9BY49

References