Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1592883..1593364 Replicon chromosome
Accession NZ_CP054125
Organism Bordetella pertussis strain NZ3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ57_RS07840 Protein ID WP_225975616.1
Coordinates 1593185..1593364 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ57_RS07835 Protein ID WP_019247905.1
Coordinates 1592883..1593182 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ57_RS07825 (HRJ57_07815) 1588991..1589665 - 675 WP_010930489.1 response regulator transcription factor -
HRJ57_RS07830 (HRJ57_07820) 1589795..1592869 + 3075 WP_023995112.1 autotransporter SphB2 -
HRJ57_RS07835 (HRJ57_07825) 1592883..1593182 - 300 WP_019247905.1 NadS family protein Antitoxin
HRJ57_RS07840 (HRJ57_07830) 1593185..1593364 - 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ57_RS07845 (HRJ57_07835) 1593497..1594120 - 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ57_RS07850 (HRJ57_07840) 1594364..1595233 + 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ57_RS07855 (HRJ57_07845) 1595211..1596155 - 945 WP_080363416.1 LysR family transcriptional regulator -
HRJ57_RS07860 (HRJ57_07850) 1596241..1597263 - 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ57_RS07865 (HRJ57_07855) 1597280..1598053 - 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158740 WP_225975616.1 NZ_CP054125:c1593364-1593185 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158740 NZ_CP069798:c1095670-1095407 [Paralysiella testudinis]
ATGATGTTGGCGTGGGCCGATGATGCTTGGGACGATTATCTGTATTGGCAGCAAACCGACAAACGCATGTTGAAACGCAT
CAATATGCTGCTGAAAGACATTCAGCGCCAGCCATTTAGCGGATTGGGTGATCCTGAACCGCTGAAACACAATTGGTCAG
ATTTCTGGTCACGCCGCATCGACAAAGAGCACCGGCTGGTTTACCGCGTCAGTAATGATATGGTGATGGTGGCACAGTGC
CGTTACCACTATGGCAAGCTTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158740 WP_019247905.1 NZ_CP054125:c1593182-1592883 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158740 NZ_CP069798:c1095921-1095667 [Paralysiella testudinis]
ATGGATACCATGAGCTACTCTGCTTTTCGCGCCGGATTGGCCGGAGTGCTGGATAAGGTCAACGACAACCACAAGCCGGT
TTTGGTGACCCGCCAAAACGGCAAACCGGCTGTGGTGATGAGTTTGGAAGATTTTCAGTCTTACGAAGAAACCGCCTATC
TTATGGCCAGCCCCCCTAATGCCGAGCGCCTAAACCGGGCAGTGGCGCAGATTCGCGCCGGAGAAACACAACAACACGGG
ATGCTGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References