Detailed information of TA system TA158739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1439817..1440472
• Replicon: chromosome
• Accession: NZ_CP054125
• Organism: Bordetella pertussis strain NZ3

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: HRJ57_RS07140
• Protein ID: WP_047122780.1
• Coordinates: 1439817..1440068 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: HRJ57_RS07145
• Protein ID: WP_003809516.1
• Coordinates: 1440071..1440472 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ57_RS07115 (HRJ57_07100)	1434978..1436108	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
HRJ57_RS07120 (HRJ57_07105)	1436343..1436924	+	582	WP_019247931.1	MOSC domain-containing protein	-
HRJ57_RS07125 (HRJ57_07110)	1437061..1438125	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
HRJ57_RS07130 (HRJ57_07115)	1438210..1438656	-	447	WP_003819827.1	GFA family protein	-
HRJ57_RS07135 (HRJ57_07120)	1438881..1439762	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HRJ57_RS07140 (HRJ57_07125)	1439817..1440068	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
HRJ57_RS07145 (HRJ57_07130)	1440071..1440472	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HRJ57_RS07150 (HRJ57_07135)	1440492..1440728	+	237	WP_010930404.1	DUF5993 family protein	-
HRJ57_RS07155 (HRJ57_07140)	1440736..1441215	+	480	WP_010930405.1	disulfide bond formation protein B	-
HRJ57_RS07160 (HRJ57_07145)	1441365..1441880	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HRJ57_RS07165 (HRJ57_07150)	1441883..1443073	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HRJ57_RS07170 (HRJ57_07155)	1443093..1444130	+	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
HRJ57_RS07175 (HRJ57_07160)	1444267..1445289	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T158739 WP_047122780.1 NZ_CP054125:1439817-1440068 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T158739 NZ_CP069798:1091282-1091689 [Paralysiella testudinis]
ATGCTGAAATATATGCTGGACACTAATATCTGCATCTACACCATGAAAAATAAGCCTGAAGAAGTGCGCCAAGCCTTTAA
CCTGCATCACACGCAAATGTGCATCAGTTCGGTGGTGTTGATGGAATTGGTATTCGGTGCTGAAAAATCAGCACGGGCGC
AAGAAGCATTTGCGGCTGTGGAAGGTTTTGCGGCTAGGATGATGGTACTGGATTTTGATGAAGCCGCCGCATACCACACC
GGACAAATCCGCGCCGAACTGAAAAAGGCCGGCAAACCGATTGGTAGTTACGACTGCATGATTGCAGGACATGCCCGTAG
CCGGGGTTTAATCGTGGTCAGCAATAATTTAAGGGAATTTGACTGTATTTCGGGATTAAGAACTGAAAATTGGGTGGCTG
CACAATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT158739 WP_003809516.1 NZ_CP054125:1440071-1440472 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT158739 NZ_CP069798:1091055-1091282 [Paralysiella testudinis]
ATGCAGGCATCTATTTTTAAGAGCAATAAAAGCCAAGCTGTACGCCTACCGAAACAGGTCGCTTTCCCCGAAGAGGTAAA
ACGGGTGGAGGTAGTGGTTATTGGACGTACACGTGTGCTGATGCCTGCGGATGAGGTTTGGGATACTTGGTTTGCAGCAT
CCCCGGTTCCTGATGATTTTATGAGTGAACGGGCGCAGCCGGCAGCACAAGAACGGGATGCTTTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6