Detailed information of TA system TA158736

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2529871..2530526
• Replicon: chromosome
• Accession: NZ_CP054123
• Organism: Bordetella pertussis strain NZ6

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: HRJ60_RS12200
• Protein ID: WP_047122780.1
• Coordinates: 2530275..2530526 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: HRJ60_RS12195
• Protein ID: WP_003809516.1
• Coordinates: 2529871..2530272 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ60_RS12165 (HRJ60_12095)	2525054..2526076	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
HRJ60_RS12170 (HRJ60_12100)	2526213..2527250	-	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
HRJ60_RS12175 (HRJ60_12105)	2527270..2528460	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HRJ60_RS12180 (HRJ60_12110)	2528463..2528978	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HRJ60_RS12185 (HRJ60_12115)	2529128..2529607	-	480	WP_010930405.1	disulfide bond formation protein B	-
HRJ60_RS12190 (HRJ60_12120)	2529615..2529851	-	237	WP_010930404.1	DUF5993 family protein	-
HRJ60_RS12195 (HRJ60_12125)	2529871..2530272	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HRJ60_RS12200 (HRJ60_12130)	2530275..2530526	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
HRJ60_RS12205 (HRJ60_12135)	2530581..2531462	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HRJ60_RS12210 (HRJ60_12140)	2531687..2532133	+	447	WP_003819827.1	GFA family protein	-
HRJ60_RS12215 (HRJ60_12145)	2532218..2533282	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
HRJ60_RS12220 (HRJ60_12150)	2533419..2534000	-	582	WP_019247931.1	MOSC domain-containing protein	-
HRJ60_RS12225 (HRJ60_12155)	2534235..2535365	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T158736 WP_047122780.1 NZ_CP054123:c2530526-2530275 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T158736 NZ_CP069797:1978379-1978777 [Actinobacillus pleuropneumoniae]
ATGCTAACTTATATGCTTGATACTAACATTGCGATTTATGTGATTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCTACCCGTCTTTGTATAAGTAGTATCACTGCAGCGGAGCTGTATTATGGTGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGCAAGGTAAGATCATTGGCGAGAACGATATTCATATTGCCGCACATGCAAGAAG
TGAAGGACTCGTATTAGTAACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTGCGATTAGATAATTGGGTATAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT158736 WP_003809516.1 NZ_CP054123:c2530272-2529871 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT158736 NZ_CP069797:1978149-1978379 [Actinobacillus pleuropneumoniae]
ATGGAAGCATCAGTATTTATGACAAACCGTAGTCAGGCGGTACGATTACCTGCAGAAGTGCGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTGGTAGGCAATGAACGTATTTTGGCTCCAATTAACCAAAGTTGGGATAGCTTCTTTCTGAGTT
CGGCAACGGTAAGCGATGATTTCATGACAGAGCGTGAAATCAGCACTCAAGCCGAACGTGAGGAACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6