Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1741738..1742219 Replicon chromosome
Accession NZ_CP054122
Organism Bordetella pertussis strain NZ7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ61_RS08445 Protein ID WP_225975616.1
Coordinates 1742040..1742219 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ61_RS08440 Protein ID WP_019247905.1
Coordinates 1741738..1742037 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ61_RS08430 (HRJ61_08370) 1737846..1738520 - 675 WP_010930489.1 response regulator transcription factor -
HRJ61_RS08435 (HRJ61_08375) 1738650..1741724 + 3075 WP_023995112.1 autotransporter SphB2 -
HRJ61_RS08440 (HRJ61_08380) 1741738..1742037 - 300 WP_019247905.1 NadS family protein Antitoxin
HRJ61_RS08445 (HRJ61_08385) 1742040..1742219 - 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ61_RS08450 (HRJ61_08390) 1742352..1742975 - 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ61_RS08455 (HRJ61_08395) 1743219..1744088 + 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ61_RS08460 (HRJ61_08400) 1744066..1745010 - 945 WP_010930494.1 LysR family transcriptional regulator -
HRJ61_RS08465 (HRJ61_08405) 1745096..1746118 - 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ61_RS08470 (HRJ61_08410) 1746135..1746908 - 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158733 WP_225975616.1 NZ_CP054122:c1742219-1742040 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158733 NZ_CP069797:c176485-176234 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACAATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATAGTTCACTTGAAGAAACCGCCTATT
TAATGCGTTCCCCGGCTAACGCTCAAAGATTACTAGACAGCATGGCAGAATTGAAGCAAGGGAAAGGCATTGAAAGAGAG
CTAATCGAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158733 WP_019247905.1 NZ_CP054122:c1742037-1741738 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158733 NZ_CP069797:c176237-175977 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGTCTGATTAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAGCCTGAACCGCTAAAATTCAATCTTTCGG
GCTTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACACCGTGGAAGATGAAACAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References