Detailed information of TA system TA158732

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1587624..1588279
• Replicon: chromosome
• Accession: NZ_CP054122
• Organism: Bordetella pertussis strain NZ7

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: HRJ61_RS07740
• Protein ID: WP_047122780.1
• Coordinates: 1587624..1587875 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: HRJ61_RS07745
• Protein ID: WP_003809516.1
• Coordinates: 1587878..1588279 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ61_RS07715 (HRJ61_07655)	1582785..1583915	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
HRJ61_RS07720 (HRJ61_07660)	1584150..1584731	+	582	WP_019247931.1	MOSC domain-containing protein	-
HRJ61_RS07725 (HRJ61_07665)	1584868..1585932	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
HRJ61_RS07730 (HRJ61_07670)	1586017..1586463	-	447	WP_003819827.1	GFA family protein	-
HRJ61_RS07735 (HRJ61_07675)	1586688..1587569	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HRJ61_RS07740 (HRJ61_07680)	1587624..1587875	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
HRJ61_RS07745 (HRJ61_07685)	1587878..1588279	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HRJ61_RS07750 (HRJ61_07690)	1588299..1588535	+	237	WP_010930404.1	DUF5993 family protein	-
HRJ61_RS07755 (HRJ61_07695)	1588543..1589022	+	480	WP_010930405.1	disulfide bond formation protein B	-
HRJ61_RS07760 (HRJ61_07700)	1589172..1589687	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HRJ61_RS07765 (HRJ61_07705)	1589690..1590880	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HRJ61_RS07770 (HRJ61_07710)	1590900..1591937	+	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
HRJ61_RS07775 (HRJ61_07715)	1592074..1593096	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T158732 WP_047122780.1 NZ_CP054122:1587624-1587875 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T158732 NZ_CP069797:c176237-175977 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGTCTGATTAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAGCCTGAACCGCTAAAATTCAATCTTTCGG
GCTTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACACCGTGGAAGATGAAACAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT158732 WP_003809516.1 NZ_CP054122:1587878-1588279 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT158732 NZ_CP069797:c176485-176234 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACAATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATAGTTCACTTGAAGAAACCGCCTATT
TAATGCGTTCCCCGGCTAACGCTCAAAGATTACTAGACAGCATGGCAGAATTGAAGCAAGGGAAAGGCATTGAAAGAGAG
CTAATCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6