Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1732972..1733453 Replicon chromosome
Accession NZ_CP054120
Organism Bordetella pertussis strain NZ9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ63_RS08405 Protein ID WP_225975616.1
Coordinates 1733274..1733453 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ63_RS08400 Protein ID WP_019247905.1
Coordinates 1732972..1733271 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ63_RS08390 (HRJ63_08335) 1729080..1729754 - 675 WP_010930489.1 response regulator transcription factor -
HRJ63_RS08395 (HRJ63_08340) 1729884..1732958 + 3075 WP_023995112.1 autotransporter SphB2 -
HRJ63_RS08400 (HRJ63_08345) 1732972..1733271 - 300 WP_019247905.1 NadS family protein Antitoxin
HRJ63_RS08405 (HRJ63_08350) 1733274..1733453 - 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ63_RS08410 (HRJ63_08355) 1733586..1734209 - 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ63_RS08415 (HRJ63_08360) 1734453..1735322 + 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ63_RS08420 (HRJ63_08365) 1735300..1736244 - 945 WP_010930494.1 LysR family transcriptional regulator -
HRJ63_RS08425 (HRJ63_08370) 1736330..1737352 - 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ63_RS08430 (HRJ63_08375) 1737369..1738142 - 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158730 WP_225975616.1 NZ_CP054120:c1733453-1733274 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158730 NZ_CP069796:c1988401-1988003 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
ATGCTGACTTATATGCTTGATACTAACATTGCGATTTATGTGATTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCTACTCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGTTGTATTATGGTGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATTAAAGCACATTTATCTAAGTGCGGTAAGATTCTCGGCGAGAACGATATTCATATTGCCGCGCATGCAAGAAG
TGAAGGACTCGTATTAGTAACCAATAACTTACGTGAATTTGAACGTGTAGAAGGATTGCGATTAGATAATTGGGTATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158730 WP_019247905.1 NZ_CP054120:c1733271-1732972 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158730 NZ_CP069796:c1988631-1988401 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
ATGGAAGCATCAGTATTTATGACAAATCGCAGTCAAGCGGTACGATTGCCGGCAGAAGTACGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTGGTAGGTAATGAACGTATTTTGGCACCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGGT
CGGCAACGGTAAGCGATGATTTCATGACAGAGCGTGAAATCAGCATTCAGCCCGAACGTGAGGGACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References