Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2564223..2564704 Replicon chromosome
Accession NZ_CP054117
Organism Bordetella pertussis strain NZ13

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ67_RS12350 Protein ID WP_225975616.1
Coordinates 2564223..2564402 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ67_RS12355 Protein ID WP_019247905.1
Coordinates 2564405..2564704 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ67_RS12325 (HRJ67_12210) 2559534..2560307 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRJ67_RS12330 (HRJ67_12215) 2560324..2561346 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ67_RS12335 (HRJ67_12220) 2561432..2562376 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRJ67_RS12340 (HRJ67_12225) 2562354..2563223 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ67_RS12345 (HRJ67_12230) 2563467..2564090 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ67_RS12350 (HRJ67_12235) 2564223..2564402 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ67_RS12355 (HRJ67_12240) 2564405..2564704 + 300 WP_019247905.1 NadS family protein Antitoxin
HRJ67_RS12360 (HRJ67_12245) 2564718..2567792 - 3075 WP_023995112.1 autotransporter SphB2 -
HRJ67_RS12365 (HRJ67_12250) 2567922..2568596 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158726 WP_225975616.1 NZ_CP054117:2564223-2564402 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158726 NZ_CP069796:1571322-1571582 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158726 WP_019247905.1 NZ_CP054117:2564405-2564704 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158726 NZ_CP069796:1571074-1571325 [Actinobacillus pleuropneumoniae serovar 6 str. Femo]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACGATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATTGTTCACTTGAAGAAACCGCCTATT
TGATGCGTTCACCCACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAG
CTAATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References