Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1731908..1732389 Replicon chromosome
Accession NZ_CP054116
Organism Bordetella pertussis strain NZ14

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ68_RS08450 Protein ID WP_225975616.1
Coordinates 1732210..1732389 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ68_RS08445 Protein ID WP_019247905.1
Coordinates 1731908..1732207 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ68_RS08435 (HRJ68_08335) 1728016..1728690 - 675 WP_010930489.1 response regulator transcription factor -
HRJ68_RS08440 (HRJ68_08340) 1728820..1731894 + 3075 WP_023995112.1 autotransporter SphB2 -
HRJ68_RS08445 (HRJ68_08345) 1731908..1732207 - 300 WP_019247905.1 NadS family protein Antitoxin
HRJ68_RS08450 (HRJ68_08350) 1732210..1732389 - 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ68_RS08455 (HRJ68_08355) 1732522..1733145 - 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ68_RS08460 (HRJ68_08360) 1733389..1734258 + 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ68_RS08465 (HRJ68_08365) 1734236..1735180 - 945 WP_010930494.1 LysR family transcriptional regulator -
HRJ68_RS08470 (HRJ68_08370) 1735266..1736288 - 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ68_RS08475 (HRJ68_08375) 1736305..1737078 - 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158724 WP_225975616.1 NZ_CP054116:c1732389-1732210 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158724 NZ_CP069795:c2136792-2136427 [Actinobacillus pleuropneumoniae]
ATGGATACCAATGTACGACAATGGTTAGCAACGATTAAACCGAGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAAT
AAAAACGGGGATTTTACTTAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTAT
TAAGCGTTTATCAAGCTAAATCCTTTTCTATAAATAATGAAATTGCGTTACTGGCTTCTGAATACCACATTCCAAATAAA
ATGGATTTAAACGATGCTTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTT
CAACCGTTGCGATATACGTTTATTTAATCCTTTCGAACCGAATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158724 WP_019247905.1 NZ_CP054116:c1732207-1731908 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158724 NZ_CP069795:c2137142-2136855 [Actinobacillus pleuropneumoniae]
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References