Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2526731..2527386 Replicon chromosome
Accession NZ_CP054113
Organism Bordetella pertussis strain NZ17

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag HRJ71_RS12185 Protein ID WP_047122780.1
Coordinates 2527135..2527386 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag HRJ71_RS12180 Protein ID WP_003809516.1
Coordinates 2526731..2527132 (-) Length 134 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ71_RS12150 (HRJ71_12085) 2521914..2522936 - 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -
HRJ71_RS12155 (HRJ71_12090) 2523073..2524110 - 1038 WP_023853543.1 L-threonylcarbamoyladenylate synthase -
HRJ71_RS12160 (HRJ71_12095) 2524130..2525320 - 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
HRJ71_RS12165 (HRJ71_12100) 2525323..2525838 - 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
HRJ71_RS12170 (HRJ71_12105) 2525988..2526467 - 480 WP_010930405.1 disulfide bond formation protein B -
HRJ71_RS12175 (HRJ71_12110) 2526475..2526711 - 237 WP_010930404.1 DUF5993 family protein -
HRJ71_RS12180 (HRJ71_12115) 2526731..2527132 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
HRJ71_RS12185 (HRJ71_12120) 2527135..2527386 - 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
HRJ71_RS12190 (HRJ71_12125) 2527441..2528322 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HRJ71_RS12195 (HRJ71_12130) 2528547..2528993 + 447 WP_003819827.1 GFA family protein -
HRJ71_RS12200 (HRJ71_12135) 2529078..2530142 - 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
HRJ71_RS12205 (HRJ71_12140) 2530279..2530860 - 582 WP_019247931.1 MOSC domain-containing protein -
HRJ71_RS12210 (HRJ71_12145) 2531095..2532225 + 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-82)

Antitoxin

(1-131)


Sequences


Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T158721 WP_047122780.1 NZ_CP054113:c2527386-2527135 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

>T158721 NZ_CP069795:c1634071-1633700 [Actinobacillus pleuropneumoniae]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTGCTAAAAGAACG
ACAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT158721 WP_003809516.1 NZ_CP054113:c2527132-2526731 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT158721 NZ_CP069795:c1633719-1633426 [Actinobacillus pleuropneumoniae]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATTTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References