Detailed information of TA system TA158718

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1528112..1528767
• Replicon: chromosome
• Accession: NZ_CP054112
• Organism: Bordetella pertussis strain NZ18

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: HRJ72_RS07380
• Protein ID: WP_047122780.1
• Coordinates: 1528112..1528363 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: HRJ72_RS07385
• Protein ID: WP_003809516.1
• Coordinates: 1528366..1528767 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ72_RS07355 (HRJ72_07305)	1523273..1524403	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
HRJ72_RS07360 (HRJ72_07310)	1524638..1525219	+	582	WP_019247931.1	MOSC domain-containing protein	-
HRJ72_RS07365 (HRJ72_07315)	1525356..1526420	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
HRJ72_RS07370 (HRJ72_07320)	1526505..1526951	-	447	WP_003819827.1	GFA family protein	-
HRJ72_RS07375 (HRJ72_07325)	1527176..1528057	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HRJ72_RS07380 (HRJ72_07330)	1528112..1528363	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
HRJ72_RS07385 (HRJ72_07335)	1528366..1528767	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HRJ72_RS07390 (HRJ72_07340)	1528787..1529023	+	237	WP_010930404.1	DUF5993 family protein	-
HRJ72_RS07395 (HRJ72_07345)	1529031..1529510	+	480	WP_010930405.1	disulfide bond formation protein B	-
HRJ72_RS07400 (HRJ72_07350)	1529660..1530175	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HRJ72_RS07405 (HRJ72_07355)	1530178..1531368	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HRJ72_RS07410 (HRJ72_07360)	1531388..1532425	+	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
HRJ72_RS07415 (HRJ72_07365)	1532562..1533584	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T158718 WP_047122780.1 NZ_CP054112:1528112-1528363 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T158718 NZ_CP069795:c782328-781939 [Actinobacillus pleuropneumoniae]
ATGTATATGCTAGATACTAATACGGTGAGTTATTTCTTTAGGCAAGAGCCTACTGTGGTTAAGAAACTACAACAACTTAA
TCCGGAATTGATTTGTATTTCATCGGTCACGGCTGCAGAGTTGTTTTATGGTGTAAAAAAACGTAATAATCAGAAACTTA
CTGCATTTTTAAATACTTTTTTATCCGCAATTACGGTTATGGATTGGGATTATCAAGTGGCGGAAGTTTATGGTCAGCTG
CGAGCAGAGATGGAACGAGGAGGCAAAATCATGGGTGTTCAAGATCAAATGATTGGAGCTCATGCCCTAGCAACAGAATG
TATTCTTGTTTCCAGCGATAAAGCCTTTCAATTTATCCCTAATCTCGTATTAGAAAATTGGTGGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT158718 WP_003809516.1 NZ_CP054112:1528366-1528767 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT158718 NZ_CP069795:c782589-782329 [Actinobacillus pleuropneumoniae]
ATGGAAAAGGTCGCACGTTTATTTAGAAACGGACGTAATCAAGCCGTACGATTACCGGTTGAATTTGAGTTTAATGCGAA
GCAAGTTTATGTGTTTAAAGAAGCAAACGGCGATATTACGCTTTCGACACGTTCTCGCAATCAGCAAAATTGGCAGAAAG
TCTTTGAGTTATTACCAATGCTTGAATGTGATGAACAGTTTTTATCGGAAAAAGAACGCAAGCAAGAAATGGCAACTCGT
GATCCCTTTGAGGGCTTTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6