Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2373851..2374332 Replicon chromosome
Accession NZ_CP054109
Organism Bordetella pertussis strain NZ21

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ75_RS11485 Protein ID WP_225975616.1
Coordinates 2373851..2374030 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ75_RS11490 Protein ID WP_019247905.1
Coordinates 2374033..2374332 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ75_RS11460 (HRJ75_11460) 2369162..2369935 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRJ75_RS11465 (HRJ75_11465) 2369952..2370974 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ75_RS11470 (HRJ75_11470) 2371060..2372004 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRJ75_RS11475 (HRJ75_11475) 2371982..2372851 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ75_RS11480 (HRJ75_11480) 2373095..2373718 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ75_RS11485 (HRJ75_11485) 2373851..2374030 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ75_RS11490 (HRJ75_11490) 2374033..2374332 + 300 WP_019247905.1 NadS family protein Antitoxin
HRJ75_RS11495 (HRJ75_11495) 2374346..2377420 - 3075 WP_023995112.1 autotransporter SphB2 -
HRJ75_RS11500 (HRJ75_11500) 2377550..2378224 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / fim3 2341347..2502943 161596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158714 WP_225975616.1 NZ_CP054109:2373851-2374030 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158714 NZ_CP069716:28354-28605 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCTGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158714 WP_019247905.1 NZ_CP054109:2374033-2374332 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158714 NZ_CP069716:28592-28819 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References