Detailed information of TA system TA158712

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2527800..2528455
• Replicon: chromosome
• Accession: NZ_CP054107
• Organism: Bordetella pertussis strain NZ23

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: HRJ77_RS12260
• Protein ID: WP_047122780.1
• Coordinates: 2528204..2528455 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: HRJ77_RS12255
• Protein ID: WP_003809516.1
• Coordinates: 2527800..2528201 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ77_RS12225 (HRJ77_12155)	2522983..2524005	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
HRJ77_RS12230 (HRJ77_12160)	2524142..2525179	-	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
HRJ77_RS12235 (HRJ77_12165)	2525199..2526389	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HRJ77_RS12240 (HRJ77_12170)	2526392..2526907	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HRJ77_RS12245 (HRJ77_12175)	2527057..2527536	-	480	WP_010930405.1	disulfide bond formation protein B	-
HRJ77_RS12250 (HRJ77_12180)	2527544..2527780	-	237	WP_010930404.1	DUF5993 family protein	-
HRJ77_RS12255 (HRJ77_12185)	2527800..2528201	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HRJ77_RS12260 (HRJ77_12190)	2528204..2528455	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
HRJ77_RS12265 (HRJ77_12195)	2528510..2529391	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HRJ77_RS12270 (HRJ77_12200)	2529616..2530062	+	447	WP_003819827.1	GFA family protein	-
HRJ77_RS12275 (HRJ77_12205)	2530147..2531211	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
HRJ77_RS12280 (HRJ77_12210)	2531348..2531929	-	582	WP_019247931.1	MOSC domain-containing protein	-
HRJ77_RS12285 (HRJ77_12215)	2532164..2533294	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T158712 WP_047122780.1 NZ_CP054107:c2528455-2528204 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T158712 NZ_CP069713:160462-160878 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT158712 WP_003809516.1 NZ_CP054107:c2528201-2527800 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT158712 NZ_CP069713:160235-160465 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6