Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2374904..2375385 Replicon chromosome
Accession NZ_CP054107
Organism Bordetella pertussis strain NZ23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ77_RS11565 Protein ID WP_225975616.1
Coordinates 2374904..2375083 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ77_RS11570 Protein ID WP_019247905.1
Coordinates 2375086..2375385 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ77_RS11540 (HRJ77_11465) 2370215..2370988 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRJ77_RS11545 (HRJ77_11470) 2371005..2372027 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ77_RS11550 (HRJ77_11475) 2372113..2373057 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRJ77_RS11555 (HRJ77_11480) 2373035..2373904 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ77_RS11560 (HRJ77_11485) 2374148..2374771 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ77_RS11565 (HRJ77_11490) 2374904..2375083 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ77_RS11570 (HRJ77_11495) 2375086..2375385 + 300 WP_019247905.1 NadS family protein Antitoxin
HRJ77_RS11575 (HRJ77_11500) 2375399..2378473 - 3075 WP_023995112.1 autotransporter SphB2 -
HRJ77_RS11580 (HRJ77_11505) 2378603..2379277 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / fim3 2342400..2504001 161601


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158711 WP_225975616.1 NZ_CP054107:2374904-2375083 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158711 NZ_CP069713:155599-156015 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158711 WP_019247905.1 NZ_CP054107:2375086-2375385 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158711 NZ_CP069713:155372-155602 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References