Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2375943..2376424 Replicon chromosome
Accession NZ_CP054106
Organism Bordetella pertussis strain NZ24

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ78_RS11500 Protein ID WP_225975616.1
Coordinates 2375943..2376122 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ78_RS11505 Protein ID WP_019247905.1
Coordinates 2376125..2376424 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ78_RS11475 (HRJ78_11475) 2371254..2372027 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRJ78_RS11480 (HRJ78_11480) 2372044..2373066 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ78_RS11485 (HRJ78_11485) 2373152..2374096 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRJ78_RS11490 (HRJ78_11490) 2374074..2374943 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ78_RS11495 (HRJ78_11495) 2375187..2375810 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ78_RS11500 (HRJ78_11500) 2375943..2376122 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ78_RS11505 (HRJ78_11505) 2376125..2376424 + 300 WP_019247905.1 NadS family protein Antitoxin
HRJ78_RS11510 (HRJ78_11510) 2376438..2379512 - 3075 WP_023995112.1 autotransporter SphB2 -
HRJ78_RS11515 (HRJ78_11515) 2379642..2380316 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / fim3 2343439..2505040 161601


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158708 WP_225975616.1 NZ_CP054106:2375943-2376122 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158708 NZ_CP069712:c4247039-4246866 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158708 WP_019247905.1 NZ_CP054106:2376125-2376424 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158708 NZ_CP069712:c4247363-4247067 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References