Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1734027..1734508 Replicon chromosome
Accession NZ_CP054104
Organism Bordetella pertussis strain NZ26

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ80_RS08400 Protein ID WP_225975616.1
Coordinates 1734329..1734508 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ80_RS08395 Protein ID WP_019247905.1
Coordinates 1734027..1734326 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ80_RS08385 (HRJ80_08335) 1730135..1730809 - 675 WP_010930489.1 response regulator transcription factor -
HRJ80_RS08390 (HRJ80_08340) 1730939..1734013 + 3075 WP_023995112.1 autotransporter SphB2 -
HRJ80_RS08395 (HRJ80_08345) 1734027..1734326 - 300 WP_019247905.1 NadS family protein Antitoxin
HRJ80_RS08400 (HRJ80_08350) 1734329..1734508 - 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ80_RS08405 (HRJ80_08355) 1734641..1735264 - 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ80_RS08410 (HRJ80_08360) 1735508..1736377 + 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ80_RS08415 (HRJ80_08365) 1736355..1737299 - 945 WP_010930494.1 LysR family transcriptional regulator -
HRJ80_RS08420 (HRJ80_08370) 1737385..1738407 - 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ80_RS08425 (HRJ80_08375) 1738424..1739197 - 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158703 WP_225975616.1 NZ_CP054104:c1734508-1734329 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158703 NZ_CP069712:2730585-2730692 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158703 WP_019247905.1 NZ_CP054104:c1734326-1734027 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158703 NZ_CP069712:c2730538-2730472 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References