Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1579909..1580564 Replicon chromosome
Accession NZ_CP054104
Organism Bordetella pertussis strain NZ26

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag HRJ80_RS07700 Protein ID WP_047122780.1
Coordinates 1579909..1580160 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag HRJ80_RS07705 Protein ID WP_003809516.1
Coordinates 1580163..1580564 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ80_RS07675 (HRJ80_07620) 1575070..1576200 - 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -
HRJ80_RS07680 (HRJ80_07625) 1576435..1577016 + 582 WP_019247931.1 MOSC domain-containing protein -
HRJ80_RS07685 (HRJ80_07630) 1577153..1578217 + 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
HRJ80_RS07690 (HRJ80_07635) 1578302..1578748 - 447 WP_003819827.1 GFA family protein -
HRJ80_RS07695 (HRJ80_07640) 1578973..1579854 + 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HRJ80_RS07700 (HRJ80_07645) 1579909..1580160 + 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
HRJ80_RS07705 (HRJ80_07650) 1580163..1580564 + 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
HRJ80_RS07710 (HRJ80_07655) 1580584..1580820 + 237 WP_010930404.1 DUF5993 family protein -
HRJ80_RS07715 (HRJ80_07660) 1580828..1581307 + 480 WP_010930405.1 disulfide bond formation protein B -
HRJ80_RS07720 (HRJ80_07665) 1581457..1581972 + 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
HRJ80_RS07725 (HRJ80_07670) 1581975..1583165 + 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
HRJ80_RS07730 (HRJ80_07675) 1583185..1584222 + 1038 WP_023853543.1 L-threonylcarbamoyladenylate synthase -
HRJ80_RS07735 (HRJ80_07680) 1584359..1585381 + 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T158702 WP_047122780.1 NZ_CP054104:1579909-1580160 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

>T158702 NZ_CP069712:2730050-2730157 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT158702 WP_003809516.1 NZ_CP054104:1580163-1580564 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT158702 NZ_CP069712:c2730003-2729937 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References