Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1684351..1684832 Replicon chromosome
Accession NZ_CP054102
Organism Bordetella pertussis strain NZ28

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ82_RS08155 Protein ID WP_225975616.1
Coordinates 1684653..1684832 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ82_RS08150 Protein ID WP_019247905.1
Coordinates 1684351..1684650 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ82_RS08140 (HRJ82_08105) 1680459..1681133 - 675 WP_010930489.1 response regulator transcription factor -
HRJ82_RS08145 (HRJ82_08110) 1681263..1684337 + 3075 WP_023995112.1 autotransporter SphB2 -
HRJ82_RS08150 (HRJ82_08115) 1684351..1684650 - 300 WP_019247905.1 NadS family protein Antitoxin
HRJ82_RS08155 (HRJ82_08120) 1684653..1684832 - 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ82_RS08160 (HRJ82_08125) 1684965..1685588 - 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ82_RS08165 (HRJ82_08130) 1685832..1686701 + 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ82_RS08170 (HRJ82_08135) 1686679..1687623 - 945 WP_010930494.1 LysR family transcriptional regulator -
HRJ82_RS08175 (HRJ82_08140) 1687709..1688731 - 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ82_RS08180 (HRJ82_08145) 1688748..1689521 - 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158701 WP_225975616.1 NZ_CP054102:c1684832-1684653 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158701 NZ_CP069712:c2568234-2567947 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158701 WP_019247905.1 NZ_CP054102:c1684650-1684351 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158701 NZ_CP069712:c2568473-2568234 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References