Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2373271..2373752 Replicon chromosome
Accession NZ_CP054087
Organism Bordetella pertussis strain NZ44

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ98_RS11490 Protein ID WP_225975616.1
Coordinates 2373271..2373450 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ98_RS11495 Protein ID WP_019247905.1
Coordinates 2373453..2373752 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ98_RS11465 (HRJ98_11375) 2368582..2369355 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRJ98_RS11470 (HRJ98_11380) 2369372..2370394 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ98_RS11475 (HRJ98_11385) 2370480..2371424 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRJ98_RS11480 (HRJ98_11390) 2371402..2372271 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ98_RS11485 (HRJ98_11395) 2372515..2373138 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ98_RS11490 (HRJ98_11400) 2373271..2373450 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ98_RS11495 (HRJ98_11405) 2373453..2373752 + 300 WP_019247905.1 NadS family protein Antitoxin
HRJ98_RS11500 (HRJ98_11410) 2373766..2376840 - 3075 WP_023995112.1 autotransporter SphB2 -
HRJ98_RS11505 (HRJ98_11415) 2376970..2377644 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / fim3 2340775..2502346 161571


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158693 WP_225975616.1 NZ_CP054087:2373271-2373450 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158693 NZ_CP069712:1013287-1013622 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158693 WP_019247905.1 NZ_CP054087:2373453-2373752 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158693 NZ_CP069712:1013039-1013287 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References