Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1736009..1736490 Replicon chromosome
Accession NZ_CP054085
Organism Bordetella pertussis strain NZ46

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRK02_RS08410 Protein ID WP_225975616.1
Coordinates 1736311..1736490 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRK02_RS08405 Protein ID WP_019247905.1
Coordinates 1736009..1736308 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRK02_RS08395 (HRK02_08345) 1732117..1732791 - 675 WP_010930489.1 response regulator transcription factor -
HRK02_RS08400 (HRK02_08350) 1732921..1735995 + 3075 WP_023995112.1 autotransporter SphB2 -
HRK02_RS08405 (HRK02_08355) 1736009..1736308 - 300 WP_019247905.1 NadS family protein Antitoxin
HRK02_RS08410 (HRK02_08360) 1736311..1736490 - 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRK02_RS08415 (HRK02_08365) 1736623..1737246 - 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRK02_RS08420 (HRK02_08370) 1737490..1738359 + 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRK02_RS08425 (HRK02_08375) 1738337..1739281 - 945 WP_010930494.1 LysR family transcriptional regulator -
HRK02_RS08430 (HRK02_08380) 1739367..1740389 - 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRK02_RS08435 (HRK02_08385) 1740406..1741179 - 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158691 WP_225975616.1 NZ_CP054085:c1736490-1736311 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158691 NZ_CP069712:767058-767354 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158691 WP_019247905.1 NZ_CP054085:c1736308-1736009 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158691 NZ_CP069712:767356-767751 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References