Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2376999..2377480 Replicon chromosome
Accession NZ_CP054084
Organism Bordetella pertussis strain NZ47

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRJ99_RS11575 Protein ID WP_225975616.1
Coordinates 2376999..2377178 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRJ99_RS11580 Protein ID WP_019247905.1
Coordinates 2377181..2377480 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ99_RS11550 (HRJ99_11480) 2372310..2373083 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRJ99_RS11555 (HRJ99_11485) 2373100..2374122 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRJ99_RS11560 (HRJ99_11490) 2374208..2375152 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRJ99_RS11565 (HRJ99_11495) 2375130..2375999 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRJ99_RS11570 (HRJ99_11500) 2376243..2376866 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRJ99_RS11575 (HRJ99_11505) 2376999..2377178 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRJ99_RS11580 (HRJ99_11510) 2377181..2377480 + 300 WP_019247905.1 NadS family protein Antitoxin
HRJ99_RS11585 (HRJ99_11515) 2377494..2380568 - 3075 WP_023995112.1 autotransporter SphB2 -
HRJ99_RS11590 (HRJ99_11520) 2380698..2381372 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / fim3 2344495..2506097 161602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158687 WP_225975616.1 NZ_CP054084:2376999-2377178 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158687 NZ_CP069710:c4273893-4273675 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158687 WP_019247905.1 NZ_CP054084:2377181-2377480 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158687 NZ_CP069710:c4274293-4273919 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACTTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References