Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2529807..2530462 Replicon chromosome
Accession NZ_CP054079
Organism Bordetella pertussis strain NZ52

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag HRK07_RS12265 Protein ID WP_047122780.1
Coordinates 2530211..2530462 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag HRK07_RS12260 Protein ID WP_003809516.1
Coordinates 2529807..2530208 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRK07_RS12230 (HRK07_12160) 2524990..2526012 - 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -
HRK07_RS12235 (HRK07_12165) 2526149..2527186 - 1038 WP_023853543.1 L-threonylcarbamoyladenylate synthase -
HRK07_RS12240 (HRK07_12170) 2527206..2528396 - 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
HRK07_RS12245 (HRK07_12175) 2528399..2528914 - 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
HRK07_RS12250 (HRK07_12180) 2529064..2529543 - 480 WP_010930405.1 disulfide bond formation protein B -
HRK07_RS12255 (HRK07_12185) 2529551..2529787 - 237 WP_010930404.1 DUF5993 family protein -
HRK07_RS12260 (HRK07_12190) 2529807..2530208 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
HRK07_RS12265 (HRK07_12195) 2530211..2530462 - 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
HRK07_RS12270 (HRK07_12200) 2530517..2531398 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HRK07_RS12275 (HRK07_12205) 2531623..2532069 + 447 WP_003819827.1 GFA family protein -
HRK07_RS12280 (HRK07_12210) 2532154..2533218 - 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
HRK07_RS12285 (HRK07_12215) 2533355..2533936 - 582 WP_019247931.1 MOSC domain-containing protein -
HRK07_RS12290 (HRK07_12220) 2534171..2535301 + 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T158685 WP_047122780.1 NZ_CP054079:c2530462-2530211 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

>T158685 NZ_CP069710:c3775362-3775210 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT158685 WP_003809516.1 NZ_CP054079:c2530208-2529807 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT158685 NZ_CP069710:3775411-3775468 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References