Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2376927..2377408 Replicon chromosome
Accession NZ_CP054079
Organism Bordetella pertussis strain NZ52

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRK07_RS11565 Protein ID WP_225975616.1
Coordinates 2376927..2377106 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRK07_RS11570 Protein ID WP_019247905.1
Coordinates 2377109..2377408 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRK07_RS11540 (HRK07_11465) 2372238..2373011 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRK07_RS11545 (HRK07_11470) 2373028..2374050 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRK07_RS11550 (HRK07_11475) 2374136..2375080 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRK07_RS11555 (HRK07_11480) 2375058..2375927 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRK07_RS11560 (HRK07_11485) 2376171..2376794 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRK07_RS11565 (HRK07_11490) 2376927..2377106 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRK07_RS11570 (HRK07_11495) 2377109..2377408 + 300 WP_019247905.1 NadS family protein Antitoxin
HRK07_RS11575 (HRK07_11500) 2377422..2380496 - 3075 WP_023995112.1 autotransporter SphB2 -
HRK07_RS11580 (HRK07_11505) 2380626..2381300 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / fim3 2344423..2506008 161585


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158684 WP_225975616.1 NZ_CP054079:2376927-2377106 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158684 NZ_CP069710:3557366-3557716 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158684 WP_019247905.1 NZ_CP054079:2377109-2377408 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158684 NZ_CP069710:3557121-3557372 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References