Detailed information of TA system TA158682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2529897..2530552
• Replicon: chromosome
• Accession: NZ_CP054077
• Organism: Bordetella pertussis strain NZ54

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: HRK09_RS12275
• Protein ID: WP_047122780.1
• Coordinates: 2530301..2530552 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: HRK09_RS12270
• Protein ID: WP_003809516.1
• Coordinates: 2529897..2530298 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRK09_RS12240 (HRK09_12170)	2525080..2526102	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
HRK09_RS12245 (HRK09_12175)	2526239..2527276	-	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
HRK09_RS12250 (HRK09_12180)	2527296..2528486	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HRK09_RS12255 (HRK09_12185)	2528489..2529004	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HRK09_RS12260 (HRK09_12190)	2529154..2529633	-	480	WP_010930405.1	disulfide bond formation protein B	-
HRK09_RS12265 (HRK09_12195)	2529641..2529877	-	237	WP_010930404.1	DUF5993 family protein	-
HRK09_RS12270 (HRK09_12200)	2529897..2530298	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HRK09_RS12275 (HRK09_12205)	2530301..2530552	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
HRK09_RS12280 (HRK09_12210)	2530607..2531488	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HRK09_RS12285 (HRK09_12215)	2531713..2532159	+	447	WP_003819827.1	GFA family protein	-
HRK09_RS12290 (HRK09_12220)	2532244..2533308	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
HRK09_RS12295 (HRK09_12225)	2533445..2534026	-	582	WP_019247931.1	MOSC domain-containing protein	-
HRK09_RS12300 (HRK09_12230)	2534261..2535391	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T158682 WP_047122780.1 NZ_CP054077:c2530552-2530301 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T158682 NZ_CP069710:c2729065-2728790 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT158682 WP_003809516.1 NZ_CP054077:c2530298-2529897 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT158682 NZ_CP069710:c2728793-2728434 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6