Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2377001..2377482 Replicon chromosome
Accession NZ_CP054077
Organism Bordetella pertussis strain NZ54

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRK09_RS11580 Protein ID WP_225975616.1
Coordinates 2377001..2377180 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRK09_RS11585 Protein ID WP_019247905.1
Coordinates 2377183..2377482 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRK09_RS11555 (HRK09_11480) 2372312..2373085 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRK09_RS11560 (HRK09_11485) 2373102..2374124 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRK09_RS11565 (HRK09_11490) 2374210..2375154 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRK09_RS11570 (HRK09_11495) 2375132..2376001 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRK09_RS11575 (HRK09_11500) 2376245..2376868 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRK09_RS11580 (HRK09_11505) 2377001..2377180 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRK09_RS11585 (HRK09_11510) 2377183..2377482 + 300 WP_019247905.1 NadS family protein Antitoxin
HRK09_RS11590 (HRK09_11515) 2377496..2380570 - 3075 WP_023995112.1 autotransporter SphB2 -
HRK09_RS11595 (HRK09_11520) 2380700..2381374 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / fim3 2344497..2506098 161601


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158681 WP_225975616.1 NZ_CP054077:2377001-2377180 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158681 NZ_CP069710:2373606-2374070 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158681 WP_019247905.1 NZ_CP054077:2377183-2377482 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158681 NZ_CP069710:2373271-2373606 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References