Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2374903..2375384 Replicon chromosome
Accession NZ_CP054076
Organism Bordetella pertussis strain NZ55

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRK10_RS11560 Protein ID WP_225975616.1
Coordinates 2374903..2375082 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRK10_RS11565 Protein ID WP_019247905.1
Coordinates 2375085..2375384 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRK10_RS11535 (HRK10_11465) 2370214..2370987 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRK10_RS11540 (HRK10_11470) 2371004..2372026 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRK10_RS11545 (HRK10_11475) 2372112..2373056 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRK10_RS11550 (HRK10_11480) 2373034..2373903 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRK10_RS11555 (HRK10_11485) 2374147..2374770 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRK10_RS11560 (HRK10_11490) 2374903..2375082 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRK10_RS11565 (HRK10_11495) 2375085..2375384 + 300 WP_019247905.1 NadS family protein Antitoxin
HRK10_RS11570 (HRK10_11500) 2375398..2378472 - 3075 WP_023995112.1 autotransporter SphB2 -
HRK10_RS11575 (HRK10_11505) 2378602..2379276 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / fim3 2342399..2503996 161597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158678 WP_225975616.1 NZ_CP054076:2374903-2375082 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158678 NZ_CP069710:c1981545-1981210 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158678 WP_019247905.1 NZ_CP054076:2375085-2375384 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158678 NZ_CP069710:c1981793-1981545 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References