Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2375603..2376084 Replicon chromosome
Accession NZ_CP054075
Organism Bordetella pertussis strain NZ56

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRK11_RS11565 Protein ID WP_225975616.1
Coordinates 2375603..2375782 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRK11_RS11570 Protein ID WP_019247905.1
Coordinates 2375785..2376084 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRK11_RS11540 (HRK11_11460) 2370914..2371687 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRK11_RS11545 (HRK11_11465) 2371704..2372726 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRK11_RS11550 (HRK11_11470) 2372812..2373756 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRK11_RS11555 (HRK11_11475) 2373734..2374603 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRK11_RS11560 (HRK11_11480) 2374847..2375470 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRK11_RS11565 (HRK11_11485) 2375603..2375782 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRK11_RS11570 (HRK11_11490) 2375785..2376084 + 300 WP_019247905.1 NadS family protein Antitoxin
HRK11_RS11575 (HRK11_11495) 2376098..2379172 - 3075 WP_023995112.1 autotransporter SphB2 -
HRK11_RS11580 (HRK11_11500) 2379302..2379976 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / fim3 2343099..2504694 161595


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158675 WP_225975616.1 NZ_CP054075:2375603-2375782 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158675 NZ_CP069710:542418-542594 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158675 WP_019247905.1 NZ_CP054075:2375785-2376084 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158675 NZ_CP069710:542640-543056 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References