Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1651098..1651579 Replicon chromosome
Accession NZ_CP054073
Organism Bordetella pertussis strain NZ58

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRK12_RS08025 Protein ID WP_225975616.1
Coordinates 1651400..1651579 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRK12_RS08020 Protein ID WP_019247905.1
Coordinates 1651098..1651397 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRK12_RS08010 (HRK12_07960) 1647206..1647880 - 675 WP_010930489.1 response regulator transcription factor -
HRK12_RS08015 (HRK12_07965) 1648010..1651084 + 3075 WP_023995112.1 autotransporter SphB2 -
HRK12_RS08020 (HRK12_07970) 1651098..1651397 - 300 WP_019247905.1 NadS family protein Antitoxin
HRK12_RS08025 (HRK12_07975) 1651400..1651579 - 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRK12_RS08030 (HRK12_07980) 1651712..1652335 - 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRK12_RS08035 (HRK12_07985) 1652579..1653448 + 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRK12_RS08040 (HRK12_07990) 1653426..1654370 - 945 WP_010930494.1 LysR family transcriptional regulator -
HRK12_RS08045 (HRK12_07995) 1654456..1655478 - 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRK12_RS08050 (HRK12_08000) 1655495..1656268 - 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158674 WP_225975616.1 NZ_CP054073:c1651579-1651400 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158674 NZ_CP069710:c332741-332634 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158674 WP_019247905.1 NZ_CP054073:c1651397-1651098 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158674 NZ_CP069710:332788-332854 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References