Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2375666..2376147 Replicon chromosome
Accession NZ_CP054072
Organism Bordetella pertussis strain NZ59

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRK13_RS11505 Protein ID WP_225975616.1
Coordinates 2375666..2375845 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRK13_RS11510 Protein ID WP_019247905.1
Coordinates 2375848..2376147 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRK13_RS11480 (HRK13_11405) 2370977..2371750 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRK13_RS11485 (HRK13_11410) 2371767..2372789 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRK13_RS11490 (HRK13_11415) 2372875..2373819 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRK13_RS11495 (HRK13_11420) 2373797..2374666 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRK13_RS11500 (HRK13_11425) 2374910..2375533 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRK13_RS11505 (HRK13_11430) 2375666..2375845 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRK13_RS11510 (HRK13_11435) 2375848..2376147 + 300 WP_019247905.1 NadS family protein Antitoxin
HRK13_RS11515 (HRK13_11440) 2376161..2379235 - 3075 WP_023995112.1 autotransporter SphB2 -
HRK13_RS11520 (HRK13_11445) 2379365..2380039 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158669 WP_225975616.1 NZ_CP054072:2375666-2375845 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158669 NZ_CP069709:c3927891-3927604 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGTATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158669 WP_019247905.1 NZ_CP054072:2375848-2376147 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158669 NZ_CP069709:c3927617-3927315 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References