Detailed information of TA system TA158667

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2528832..2529487
• Replicon: chromosome
• Accession: NZ_CP054071
• Organism: Bordetella pertussis strain NZ60

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: HRK14_RS12195
• Protein ID: WP_047122780.1
• Coordinates: 2529236..2529487 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: HRK14_RS12190
• Protein ID: WP_003809516.1
• Coordinates: 2528832..2529233 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRK14_RS12160 (HRK14_12095)	2524015..2525037	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
HRK14_RS12165 (HRK14_12100)	2525174..2526211	-	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
HRK14_RS12170 (HRK14_12105)	2526231..2527421	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HRK14_RS12175 (HRK14_12110)	2527424..2527939	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HRK14_RS12180 (HRK14_12115)	2528089..2528568	-	480	WP_010930405.1	disulfide bond formation protein B	-
HRK14_RS12185 (HRK14_12120)	2528576..2528812	-	237	WP_010930404.1	DUF5993 family protein	-
HRK14_RS12190 (HRK14_12125)	2528832..2529233	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HRK14_RS12195 (HRK14_12130)	2529236..2529487	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
HRK14_RS12200 (HRK14_12135)	2529542..2530423	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HRK14_RS12205 (HRK14_12140)	2530648..2531094	+	447	WP_003819827.1	GFA family protein	-
HRK14_RS12210 (HRK14_12145)	2531179..2532243	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
HRK14_RS12215 (HRK14_12150)	2532380..2532961	-	582	WP_019247931.1	MOSC domain-containing protein	-
HRK14_RS12220 (HRK14_12155)	2533196..2534326	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T158667 WP_047122780.1 NZ_CP054071:c2529487-2529236 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T158667 NZ_CP069709:3629949-3630227 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT158667 WP_003809516.1 NZ_CP054071:c2529233-2528832 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT158667 NZ_CP069709:3629686-3629946 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAAGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATTAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6