Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2375945..2376426 Replicon chromosome
Accession NZ_CP054071
Organism Bordetella pertussis strain NZ60

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HRK14_RS11500 Protein ID WP_225975616.1
Coordinates 2375945..2376124 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HRK14_RS11505 Protein ID WP_019247905.1
Coordinates 2376127..2376426 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRK14_RS11475 (HRK14_11405) 2371256..2372029 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
HRK14_RS11480 (HRK14_11410) 2372046..2373068 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
HRK14_RS11485 (HRK14_11415) 2373154..2374098 + 945 WP_010930494.1 LysR family transcriptional regulator -
HRK14_RS11490 (HRK14_11420) 2374076..2374945 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
HRK14_RS11495 (HRK14_11425) 2375189..2375812 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
HRK14_RS11500 (HRK14_11430) 2375945..2376124 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRK14_RS11505 (HRK14_11435) 2376127..2376426 + 300 WP_019247905.1 NadS family protein Antitoxin
HRK14_RS11510 (HRK14_11440) 2376440..2379514 - 3075 WP_023995112.1 autotransporter SphB2 -
HRK14_RS11515 (HRK14_11445) 2379644..2380318 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / fim3 2343441..2505033 161592


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T158666 WP_225975616.1 NZ_CP054071:2375945-2376124 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T158666 NZ_CP069709:c3623895-3623497 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT158666 WP_019247905.1 NZ_CP054071:2376127-2376426 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT158666 NZ_CP069709:c3624191-3623898 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References