Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
Location | 1981607..1982234 | Replicon | chromosome |
Accession | NZ_CP054060 | ||
Organism | Edwardsiella ictaluri strain T1-1 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A411H7J1 |
Locus tag | F8539_RS09385 | Protein ID | WP_015871332.1 |
Coordinates | 1981607..1981936 (+) | Length | 110 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | C5BBM8 |
Locus tag | F8539_RS09390 | Protein ID | WP_015871333.1 |
Coordinates | 1981926..1982234 (+) | Length | 103 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F8539_RS09355 | 1977014..1977343 | - | 330 | WP_049640650.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
F8539_RS09360 | 1977318..1977548 | - | 231 | WP_015871327.1 | ParD-like family protein | - |
F8539_RS09365 | 1977680..1977924 | - | 245 | Protein_1801 | transposase | - |
F8539_RS09370 | 1978030..1978848 | - | 819 | WP_198077051.1 | hypothetical protein | - |
F8539_RS09375 | 1978913..1980253 | - | 1341 | WP_049640648.1 | Fic family protein | - |
F8539_RS09380 | 1980382..1981152 | - | 771 | WP_198077052.1 | Rha family transcriptional regulator | - |
F8539_RS09385 | 1981607..1981936 | + | 330 | WP_015871332.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
F8539_RS09390 | 1981926..1982234 | + | 309 | WP_015871333.1 | helix-turn-helix transcriptional regulator | Antitoxin |
F8539_RS09395 | 1982485..1982742 | + | 258 | WP_198077053.1 | DUF4160 domain-containing protein | - |
F8539_RS09400 | 1982752..1983264 | + | 513 | WP_015871334.1 | DUF2442 domain-containing protein | - |
F8539_RS09405 | 1983336..1983635 | - | 300 | WP_049640646.1 | XRE family transcriptional regulator | - |
F8539_RS09410 | 1983637..1983987 | - | 351 | WP_198077054.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
F8539_RS09415 | 1984037..1984348 | - | 312 | WP_049640644.1 | DUF1364 domain-containing protein | - |
F8539_RS09420 | 1984351..1984995 | - | 645 | WP_198077055.1 | DUF1367 family protein | - |
F8539_RS09425 | 1985105..1985452 | - | 348 | WP_015871339.1 | hypothetical protein | - |
F8539_RS09430 | 1985482..1986864 | - | 1383 | WP_049640642.1 | replicative DNA helicase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1936155..2004122 | 67967 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12771.78 Da Isoelectric Point: 9.6247
>T158631 WP_015871332.1 NZ_CP054060:1981607-1981936 [Edwardsiella ictaluri]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW
Download Length: 330 bp
>T158631 NZ_CP069706:3501185-3501727 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
Antitoxin
Download Length: 103 a.a. Molecular weight: 11207.86 Da Isoelectric Point: 8.5371
>AT158631 WP_015871333.1 NZ_CP054060:1981926-1982234 [Edwardsiella ictaluri]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV
Download Length: 309 bp
>AT158631 NZ_CP069706:3500890-3501201 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A411H7J1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | C5BBM8 |