Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1981607..1982234 Replicon chromosome
Accession NZ_CP054060
Organism Edwardsiella ictaluri strain T1-1

Toxin (Protein)


Gene name higB Uniprot ID A0A411H7J1
Locus tag F8539_RS09385 Protein ID WP_015871332.1
Coordinates 1981607..1981936 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID C5BBM8
Locus tag F8539_RS09390 Protein ID WP_015871333.1
Coordinates 1981926..1982234 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8539_RS09355 1977014..1977343 - 330 WP_049640650.1 type II toxin-antitoxin system RelE/ParE family toxin -
F8539_RS09360 1977318..1977548 - 231 WP_015871327.1 ParD-like family protein -
F8539_RS09365 1977680..1977924 - 245 Protein_1801 transposase -
F8539_RS09370 1978030..1978848 - 819 WP_198077051.1 hypothetical protein -
F8539_RS09375 1978913..1980253 - 1341 WP_049640648.1 Fic family protein -
F8539_RS09380 1980382..1981152 - 771 WP_198077052.1 Rha family transcriptional regulator -
F8539_RS09385 1981607..1981936 + 330 WP_015871332.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F8539_RS09390 1981926..1982234 + 309 WP_015871333.1 helix-turn-helix transcriptional regulator Antitoxin
F8539_RS09395 1982485..1982742 + 258 WP_198077053.1 DUF4160 domain-containing protein -
F8539_RS09400 1982752..1983264 + 513 WP_015871334.1 DUF2442 domain-containing protein -
F8539_RS09405 1983336..1983635 - 300 WP_049640646.1 XRE family transcriptional regulator -
F8539_RS09410 1983637..1983987 - 351 WP_198077054.1 type II toxin-antitoxin system RelE/ParE family toxin -
F8539_RS09415 1984037..1984348 - 312 WP_049640644.1 DUF1364 domain-containing protein -
F8539_RS09420 1984351..1984995 - 645 WP_198077055.1 DUF1367 family protein -
F8539_RS09425 1985105..1985452 - 348 WP_015871339.1 hypothetical protein -
F8539_RS09430 1985482..1986864 - 1383 WP_049640642.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1936155..2004122 67967


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12771.78 Da        Isoelectric Point: 9.6247

>T158631 WP_015871332.1 NZ_CP054060:1981607-1981936 [Edwardsiella ictaluri]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW

Download         Length: 330 bp

>T158631 NZ_CP069706:3501185-3501727 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11207.86 Da        Isoelectric Point: 8.5371

>AT158631 WP_015871333.1 NZ_CP054060:1981926-1982234 [Edwardsiella ictaluri]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Download         Length: 309 bp

>AT158631 NZ_CP069706:3500890-3501201 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H7J1

Antitoxin

Source ID Structure
AlphaFold DB C5BBM8

References