Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2284991..2285559 Replicon chromosome
Accession NZ_CP054058
Organism Scandinavium goeteborgense strain CCUG 66741

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A8O29_RS11750 Protein ID WP_174081310.1
Coordinates 2284991..2285269 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A8O29_RS11755 Protein ID WP_174081311.1
Coordinates 2285269..2285559 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8O29_RS11730 2280407..2281417 + 1011 WP_110508167.1 alcohol dehydrogenase AdhP -
A8O29_RS11735 2281535..2282856 + 1322 Protein_2144 IS4 family transposase -
A8O29_RS11740 2282930..2283439 - 510 WP_174081308.1 Rrf2 family transcriptional regulator -
A8O29_RS11745 2283572..2284774 + 1203 WP_174081309.1 NAD(P)/FAD-dependent oxidoreductase -
A8O29_RS11750 2284991..2285269 + 279 WP_174081310.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8O29_RS11755 2285269..2285559 + 291 WP_174081311.1 HigA family addiction module antidote protein Antitoxin
A8O29_RS11760 2285574..2286452 + 879 WP_174081312.1 aromatic amino acid DMT transporter YddG -
A8O29_RS11765 2286453..2287943 - 1491 WP_174081313.1 MFS transporter -
A8O29_RS11770 2288062..2288637 + 576 WP_174081314.1 TetR family transcriptional regulator -
A8O29_RS11775 2288819..2290210 + 1392 WP_133459757.1 NarK family nitrate/nitrite MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10610.04 Da        Isoelectric Point: 9.6583

>T158620 WP_174081310.1 NZ_CP054058:2284991-2285269 [Scandinavium goeteborgense]
MIMSFRHKGLRNLFFFDEAAGVLPSHVKRLRNRLTVLDSATKASDLNLPGYRLHALTGDRQGVWSITVSGNWRLTFEFFN
GDAHVLNYEDYH

Download         Length: 279 bp

>T158620 NZ_CP069706:934348-934755 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10263.90 Da        Isoelectric Point: 10.4836

>AT158620 WP_174081311.1 NZ_CP054058:2285269-2285559 [Scandinavium goeteborgense]
MKMANPSSPGDIIQESLDALNVSLREFARAMNIAPSTASRLITGKAALTPEMAIKLSVVIGSSAEMWLNLQTKWSLADAQ
KRVDTSGLKRLASFSG

Download         Length: 291 bp

>AT158620 NZ_CP069706:934101-934367 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References