Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 596129..596856 Replicon chromosome
Accession NZ_CP054058
Organism Scandinavium goeteborgense strain CCUG 66741

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A8O29_RS03650 Protein ID WP_125355288.1
Coordinates 596129..596443 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A8O29_RS03655 Protein ID WP_125355289.1
Coordinates 596440..596856 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8O29_RS03630 591882..592850 - 969 WP_110510491.1 TerC family protein -
A8O29_RS03635 593120..594118 - 999 WP_125355286.1 Gfo/Idh/MocA family oxidoreductase -
A8O29_RS03640 594191..594691 - 501 WP_110510489.1 M48 family metallopeptidase -
A8O29_RS03645 594776..595912 + 1137 WP_125355287.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
A8O29_RS03650 596129..596443 + 315 WP_125355288.1 type II toxin-antitoxin system HigB family toxin Toxin
A8O29_RS03655 596440..596856 + 417 WP_125355289.1 helix-turn-helix domain-containing protein Antitoxin
A8O29_RS03660 596889..598910 - 2022 WP_125355290.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
A8O29_RS03665 599037..600341 - 1305 WP_125355291.1 HAMP domain-containing protein -
A8O29_RS03670 600338..601078 - 741 WP_125355292.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-134)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12439.54 Da        Isoelectric Point: 10.1218

>T158609 WP_125355288.1 NZ_CP054058:596129-596443 [Scandinavium goeteborgense]
MHLIAFKALTDAAKKFPQHEQELLELGGMIHKGYFKTPQSLRTLFPSLDNFKYLDKYYVLNLGHNELRLVALIFFESQKF
YVRHIFTHREYDMFTAMHRTKGKK

Download         Length: 315 bp

>T158609 NZ_CP069695:c7761-7513 [Escherichia coli H20]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15166.83 Da        Isoelectric Point: 7.3572

>AT158609 WP_125355289.1 NZ_CP054058:596440-596856 [Scandinavium goeteborgense]
MMVIADILKAGKALSAAAPFLAGIHTPQQYEEALEFVEYLLLNDPTNPLLDTACNHITAYENLLPETADFIARMNAIPIG
VAVLRTLMSQHNLTLSDFPEIGSKSMVSRVLNGKRKLTLMHAKKLAKRFGISPAMFID

Download         Length: 417 bp

>AT158609 NZ_CP069695:c7516-7169 [Escherichia coli H20]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References