Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
Location | 3842861..3844191 | Replicon | chromosome |
Accession | NZ_CP054048 | ||
Organism | Yersinia massiliensis strain 2011N-4075 |
Toxin (Protein)
Gene name | HipT | Uniprot ID | A0A2R4NNK4 |
Locus tag | HRD68_RS18320 | Protein ID | WP_050286363.1 |
Coordinates | 3842861..3843883 (-) | Length | 341 a.a. |
Antitoxin (Protein)
Gene name | HipS | Uniprot ID | A0A0T9T098 |
Locus tag | HRD68_RS18325 | Protein ID | WP_050079781.1 |
Coordinates | 3843880..3844191 (-) | Length | 104 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HRD68_RS18305 | 3839072..3840496 | + | 1425 | WP_167311297.1 | EmmdR/YeeO family multidrug/toxin efflux MATE transporter | - |
HRD68_RS18310 | 3840664..3841638 | + | 975 | WP_050286361.1 | chemotaxis protein | - |
HRD68_RS18315 | 3841871..3842653 | + | 783 | WP_050079783.1 | SDR family oxidoreductase | - |
HRD68_RS18320 | 3842861..3843883 | - | 1023 | WP_050286363.1 | HipA domain-containing protein | Toxin |
HRD68_RS18325 | 3843880..3844191 | - | 312 | WP_050079781.1 | HipA N-terminal domain-containing protein | Antitoxin |
HRD68_RS18330 | 3844176..3844520 | - | 345 | WP_050079780.1 | hypothetical protein | - |
HRD68_RS18335 | 3844887..3845501 | + | 615 | WP_050079779.1 | TetR/AcrR family transcriptional regulator | - |
HRD68_RS18340 | 3845576..3846685 | + | 1110 | WP_050079778.1 | efflux RND transporter periplasmic adaptor subunit | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 341 a.a. Molecular weight: 38276.09 Da Isoelectric Point: 6.9755
>T158573 WP_050286363.1 NZ_CP054048:c3843883-3842861 [Yersinia massiliensis]
MNPEHCLINLSRLKGAELKTGYSTKGIRHLFGRLEVALSLPFTRSQFIQELPERQKGMSISGYQPKLSLRLEGGELMVVS
NDGTYILKPSPEEYPHLAENEHATMCVMQRLKFEIPPFGLIAFKRDDNRSDELAFVIKRYDRLGADIMRLHQEQLDGAMG
LGDKYGNIDNKKAISYEKAAKFLNKSVSSSLKSMRDVFLRIVYAYILGNNDFHLRNFGIIHPEKGSSYLAPVYDFISVVP
YPAAFGEYLALPLLEREENDAASAPGLDSAYGEYLGADFILLAQGIGINPVLAKKWLTDVIKSHQLIIDTYTESHMPEAQ
REAVLKYVARRITLLAVTEL
MNPEHCLINLSRLKGAELKTGYSTKGIRHLFGRLEVALSLPFTRSQFIQELPERQKGMSISGYQPKLSLRLEGGELMVVS
NDGTYILKPSPEEYPHLAENEHATMCVMQRLKFEIPPFGLIAFKRDDNRSDELAFVIKRYDRLGADIMRLHQEQLDGAMG
LGDKYGNIDNKKAISYEKAAKFLNKSVSSSLKSMRDVFLRIVYAYILGNNDFHLRNFGIIHPEKGSSYLAPVYDFISVVP
YPAAFGEYLALPLLEREENDAASAPGLDSAYGEYLGADFILLAQGIGINPVLAKKWLTDVIKSHQLIIDTYTESHMPEAQ
REAVLKYVARRITLLAVTEL
Download Length: 1023 bp
>T158573 NZ_CP069677:c4507226-4506876 [Escherichia coli O126:H45]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 104 a.a. Molecular weight: 11748.64 Da Isoelectric Point: 6.9762
>AT158573 WP_050079781.1 NZ_CP054048:c3844191-3843880 [Yersinia massiliensis]
MARKIGVWLYNKPVGTLSEEDIGFAFCYLANYTGRPISLSMPIRPEPYINQELHPFFKGLAPEGWLRKRYSEIQKIDDKD
LFGLLMQNGNDLLGAVVLKEITS
MARKIGVWLYNKPVGTLSEEDIGFAFCYLANYTGRPISLSMPIRPEPYINQELHPFFKGLAPEGWLRKRYSEIQKIDDKD
LFGLLMQNGNDLLGAVVLKEITS
Download Length: 312 bp
>AT158573 NZ_CP069677:c4507471-4507220 [Escherichia coli O126:H45]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCTTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCTTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2R4NNK4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0T9T098 |