Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3842861..3844191 Replicon chromosome
Accession NZ_CP054048
Organism Yersinia massiliensis strain 2011N-4075

Toxin (Protein)


Gene name HipT Uniprot ID A0A2R4NNK4
Locus tag HRD68_RS18320 Protein ID WP_050286363.1
Coordinates 3842861..3843883 (-) Length 341 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0T9T098
Locus tag HRD68_RS18325 Protein ID WP_050079781.1
Coordinates 3843880..3844191 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD68_RS18305 3839072..3840496 + 1425 WP_167311297.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
HRD68_RS18310 3840664..3841638 + 975 WP_050286361.1 chemotaxis protein -
HRD68_RS18315 3841871..3842653 + 783 WP_050079783.1 SDR family oxidoreductase -
HRD68_RS18320 3842861..3843883 - 1023 WP_050286363.1 HipA domain-containing protein Toxin
HRD68_RS18325 3843880..3844191 - 312 WP_050079781.1 HipA N-terminal domain-containing protein Antitoxin
HRD68_RS18330 3844176..3844520 - 345 WP_050079780.1 hypothetical protein -
HRD68_RS18335 3844887..3845501 + 615 WP_050079779.1 TetR/AcrR family transcriptional regulator -
HRD68_RS18340 3845576..3846685 + 1110 WP_050079778.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 341 a.a.        Molecular weight: 38276.09 Da        Isoelectric Point: 6.9755

>T158573 WP_050286363.1 NZ_CP054048:c3843883-3842861 [Yersinia massiliensis]
MNPEHCLINLSRLKGAELKTGYSTKGIRHLFGRLEVALSLPFTRSQFIQELPERQKGMSISGYQPKLSLRLEGGELMVVS
NDGTYILKPSPEEYPHLAENEHATMCVMQRLKFEIPPFGLIAFKRDDNRSDELAFVIKRYDRLGADIMRLHQEQLDGAMG
LGDKYGNIDNKKAISYEKAAKFLNKSVSSSLKSMRDVFLRIVYAYILGNNDFHLRNFGIIHPEKGSSYLAPVYDFISVVP
YPAAFGEYLALPLLEREENDAASAPGLDSAYGEYLGADFILLAQGIGINPVLAKKWLTDVIKSHQLIIDTYTESHMPEAQ
REAVLKYVARRITLLAVTEL

Download         Length: 1023 bp

>T158573 NZ_CP069677:c4507226-4506876 [Escherichia coli O126:H45]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11748.64 Da        Isoelectric Point: 6.9762

>AT158573 WP_050079781.1 NZ_CP054048:c3844191-3843880 [Yersinia massiliensis]
MARKIGVWLYNKPVGTLSEEDIGFAFCYLANYTGRPISLSMPIRPEPYINQELHPFFKGLAPEGWLRKRYSEIQKIDDKD
LFGLLMQNGNDLLGAVVLKEITS

Download         Length: 312 bp

>AT158573 NZ_CP069677:c4507471-4507220 [Escherichia coli O126:H45]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCTTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R4NNK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9T098

References