Detailed information of TA system TA158572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 3413022..3413693
• Replicon: chromosome
• Accession: NZ_CP054048
• Organism: Yersinia massiliensis strain 2011N-4075

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0T9T807
• Locus tag: HRD68_RS16245
• Protein ID: WP_050080100.1
• Coordinates: 3413022..3413354 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HRD68_RS16250
• Protein ID: WP_050080099.1
• Coordinates: 3413373..3413693 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRD68_RS16225	3408624..3410282	+	1659	WP_050080104.1	indolepyruvate decarboxylase	-
HRD68_RS16230	3410257..3411141	-	885	WP_050080103.1	LysR family transcriptional regulator	-
HRD68_RS16235	3411243..3411725	+	483	WP_050080102.1	multidrug/biocide efflux PACE transporter	-
HRD68_RS16240	3411894..3412865	+	972	WP_050287338.1	glucokinase	-
HRD68_RS16245	3413022..3413354	+	333	WP_050080100.1	toxin	Toxin
HRD68_RS16250	3413373..3413693	+	321	WP_050080099.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
HRD68_RS16255	3413719..3414963	-	1245	WP_057649765.1	OFA family MFS transporter	-
HRD68_RS16260	3415177..3415917	-	741	WP_050080097.1	LytTR family DNA-binding domain-containing protein	-
HRD68_RS16265	3415921..3417621	-	1701	WP_050080096.1	sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin MqsA/HigA-2 (35-99)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12914.87 Da
• Isoelectric Point: 10.1237

>T158572 WP_050080100.1 NZ_CP054048:3413022-3413354 [Yersinia massiliensis]
MDAVFIELPPFERVRLDYLSDDDYRTLQTALMNNPTVGDVIQQTGGLRKMRFSEAKTGKGKRSGVRVIYYWWVERFQFLL
FTIYSKGEMSDLTHSQRKILSNLLKSRKSE

Nucleotide

• Length: 333 bp

>T158572 NZ_CP069677:c4430434-4430063 [Escherichia coli O126:H45]
ATGCAAACTATATCATCACACCCGACACGGGCGACTCAGCCCTGCCTGTCACCCGTTGAAATCTGGCAGCGGTTACTGAC
TTGTCTGTTGTCGCAGCACTATGGTCTGACGTTGAATGACACACCGTTCAGTAATGAAACCACCATACTGGAACACATTG
ATGCTGGAGTATCGCTGTGCGATGCGGTGAACTTTCTTGTTGAAAAATATGAACTGGTAAGAATTGACTGTAATGATTGC
TCTGTCATGGAGAAGTCACCGTTCATCACCAGTATCGATATTCTACGTGCCCGGAAAGCCTCCGGTCTGATGAAACGCAA
CAGTCACAAAACTGTTACCAGGGTAACGGCAGGTCGACTTCAGGAGCTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12162.92 Da
• Isoelectric Point: 8.5292

>AT158572 WP_050080099.1 NZ_CP054048:3413373-3413693 [Yersinia massiliensis]
MKKRDLFSELVEGMEAWGEANTGKKTLKTHKVSTENTVTLTSEELRHIRETLNISQALFAHYLQAGIATYQNWEQGRAKP
NKQAILLIKMVQKDPHTLHTLAELYE

Nucleotide

• Length: 321 bp

>AT158572 NZ_CP069677:c4430838-4430473 [Escherichia coli O126:H45]
ATGAACAATCACTCAGAATCCGGTACAAAGCCGGAGAATCCCGCCTGCCAGCAGTGGGGGCTTAAATGTGCTATTACCCC
CTGTTTTGGTGCCCGCCTGGTACAGGAGGGCAACCGATTGCATTTTCTCTCTGACCGCGCAGGATTTAGCGGGGCATTTG
CCGTCGATGTTGCAATGCGCCTTGACCAGGCATTTCCGTTAATGATGAAGCAACTTGAGCTGATGCTGACCAGTGGAGAG
CTTAACCCTCGCCACCCACACTGCGTCACGCTTTACCACAATGGACTCACCTGTGAAGCCGATACACTAGGCTCCTGTGG
TTATGTCTACATTGCTATCTATCCTGAGCAAACTGAGCCGCAGTAA

Structures

Toxin

• AlphaFold DB: A0A0T9T807