Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 34315..34817 Replicon plasmid unnamed1
Accession NZ_CP054046
Organism Yersinia massiliensis strain 2011N-4075

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0T9QE21
Locus tag HRD68_RS00195 Protein ID WP_050116472.1
Coordinates 34315..34569 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0T9R012
Locus tag HRD68_RS00200 Protein ID WP_050116471.1
Coordinates 34566..34817 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD68_RS00165 29943..31115 - 1173 WP_172986744.1 TriI protein -
HRD68_RS00170 31139..32014 - 876 WP_172986745.1 P-type conjugative transfer protein VirB9 -
HRD68_RS00175 32143..32826 - 684 WP_172986722.1 type IV secretion system protein -
HRD68_RS00180 32801..32947 - 147 WP_172986723.1 hypothetical protein -
HRD68_RS00185 32996..34015 - 1020 WP_172986724.1 type IV secretion system protein -
HRD68_RS00190 34027..34266 - 240 WP_172986725.1 EexN family lipoprotein -
HRD68_RS00195 34315..34569 - 255 WP_050116472.1 Txe/YoeB family addiction module toxin Toxin
HRD68_RS00200 34566..34817 - 252 WP_050116471.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HRD68_RS00205 34884..35597 - 714 WP_172986726.1 type IV secretion system protein -
HRD68_RS00210 35672..38419 - 2748 WP_172986727.1 VirB3 family type IV secretion system protein -
HRD68_RS00215 38438..38728 - 291 WP_172986728.1 TrbC/VirB2 family protein -
HRD68_RS00220 38732..39343 - 612 WP_172986729.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..124188 124188


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10142.69 Da        Isoelectric Point: 9.3335

>T158562 WP_050116472.1 NZ_CP054046:c34569-34315 [Yersinia massiliensis]
MKIVFSSQSWEDYLYWQQTDKKILKRINELIKDIQRMPFEGKGKPEPLKYNLSGFWSRRITEEHRLVYEVAGDSVLIAAC
RYHY

Download         Length: 255 bp

>T158562 NZ_CP069677:1432881-1433279 [Escherichia coli O126:H45]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.58 Da        Isoelectric Point: 4.7996

>AT158562 WP_050116471.1 NZ_CP054046:c34817-34566 [Yersinia massiliensis]
MRTVNYSEARQNLAATMVKTVEDRAPILITRQNGSACVLMSLEEYESLEETAYLMRSPANAMNLMSSIEELRGGKGTERK
LAE

Download         Length: 252 bp

>AT158562 NZ_CP069677:1432654-1432881 [Escherichia coli O126:H45]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9QE21

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9R012

References