Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 1040425..1041293 | Replicon | chromosome |
| Accession | NZ_CP054014 | ||
| Organism | Mycobacterium tuberculosis strain FDAARGOS_756 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | FOC64_RS05180 | Protein ID | WP_010886136.1 |
| Coordinates | 1040916..1041293 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | FOC64_RS05175 | Protein ID | WP_003409886.1 |
| Coordinates | 1040425..1040874 (-) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOC64_RS05135 | 1036210..1037430 | + | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FOC64_RS05140 | 1037463..1037735 | + | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FOC64_RS05145 | 1037739..1038146 | + | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FOC64_RS05150 | 1038306..1038800 | - | 495 | WP_003899099.1 | hypothetical protein | - |
| FOC64_RS05155 | 1038787..1039038 | + | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FOC64_RS05160 | 1039035..1039331 | + | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FOC64_RS05165 | 1039380..1039994 | + | 615 | WP_003901296.1 | hypothetical protein | - |
| FOC64_RS05170 | 1039883..1040428 | - | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FOC64_RS05175 | 1040425..1040874 | - | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| FOC64_RS05180 | 1040916..1041293 | - | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| FOC64_RS05185 | 1041268..1041789 | + | 522 | WP_003904745.1 | hypothetical protein | - |
| FOC64_RS05190 | 1041763..1042074 | - | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FOC64_RS05195 | 1042071..1042286 | - | 216 | WP_003409878.1 | antitoxin | - |
| FOC64_RS05200 | 1042526..1042822 | + | 297 | WP_003409877.1 | hypothetical protein | - |
| FOC64_RS05205 | 1042823..1043014 | + | 192 | WP_003409876.1 | hypothetical protein | - |
| FOC64_RS05210 | 1043035..1043937 | + | 903 | WP_003899097.1 | hypothetical protein | - |
| FOC64_RS05215 | 1043948..1044298 | + | 351 | WP_003409871.1 | hypothetical protein | - |
| FOC64_RS05220 | 1044412..1044594 | + | 183 | WP_003409870.1 | hypothetical protein | - |
| FOC64_RS05225 | 1044587..1044988 | - | 402 | WP_003409869.1 | hypothetical protein | - |
| FOC64_RS05230 | 1045052..1045504 | + | 453 | WP_003899095.1 | lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T158475 WP_010886136.1 NZ_CP054014:c1041293-1040916 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T158475 NZ_CP069642:c3746969-3746592 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT158475 WP_003409886.1 NZ_CP054014:c1040874-1040425 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT158475 NZ_CP069642:c3747390-3747016 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|