Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 3820753..3821401 Replicon chromosome
Accession NZ_CP054013
Organism Mycobacterium tuberculosis strain FDAARGOS_757

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FOC65_RS17770 Protein ID WP_003899414.1
Coordinates 3820753..3821076 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FOC65_RS17775 Protein ID WP_003899415.1
Coordinates 3821156..3821401 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC65_RS17750 3816327..3817588 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FOC65_RS17755 3817962..3819401 - 1440 WP_009935349.1 phage major capsid protein -
FOC65_RS17760 3819409..3819942 - 534 WP_003899412.1 HK97 family phage prohead protease -
FOC65_RS17765 3820095..3820721 - 627 WP_003899413.1 phage terminase small subunit P27 family -
FOC65_RS17770 3820753..3821076 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FOC65_RS17775 3821156..3821401 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FOC65_RS17780 3821398..3822825 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FOC65_RS17785 3822827..3823219 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FOC65_RS17790 3823216..3823476 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FOC65_RS17795 3823493..3823855 - 363 WP_003900543.1 hypothetical protein -
FOC65_RS17800 3823858..3824985 - 1128 WP_003899420.1 site-specific integrase -
FOC65_RS17805 3825130..3825357 - 228 WP_003899421.1 hypothetical protein -
FOC65_RS17810 3825354..3825743 - 390 WP_003899422.1 hypothetical protein -
FOC65_RS17815 3825649..3825921 + 273 WP_003900544.1 hypothetical protein -
FOC65_RS17820 3826020..3826253 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3814718..3824985 10267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T158443 WP_003899414.1 NZ_CP054013:c3821076-3820753 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T158443 NZ_CP069639:c1661140-1660733 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT158443 WP_003899415.1 NZ_CP054013:c3821401-3821156 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT158443 NZ_CP069639:c1661387-1661121 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References