Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2197230..2197743 Replicon chromosome
Accession NZ_CP053957
Organism Staphylococcus capitis strain FDAARGOS_753

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4U9TK67
Locus tag FOC61_RS10745 Protein ID WP_002452576.1
Coordinates 2197230..2197496 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B5RQB4
Locus tag FOC61_RS10750 Protein ID WP_002452575.1
Coordinates 2197489..2197743 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC61_RS10725 2193119..2194558 + 1440 WP_039973741.1 DDE-type integrase/transposase/recombinase -
FOC61_RS10730 2194551..2195386 + 836 Protein_2081 AAA family ATPase -
FOC61_RS10735 2195406..2195966 + 561 WP_002452578.1 recombinase family protein -
FOC61_RS10740 2196069..2196617 + 549 WP_016898838.1 recombinase family protein -
FOC61_RS10745 2197230..2197496 - 267 WP_002452576.1 Txe/YoeB family addiction module toxin Toxin
FOC61_RS10750 2197489..2197743 - 255 WP_002452575.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOC61_RS10755 2197867..2198040 + 174 WP_080003825.1 plasmid recombination protein -
FOC61_RS10760 2198667..2199025 - 359 Protein_2087 replication protein -
FOC61_RS10765 2199472..2199960 - 489 Protein_2088 RepB family plasmid replication initiator protein -
FOC61_RS10770 2200264..2200431 + 168 WP_002452554.1 hypothetical protein -
FOC61_RS10775 2200564..2201238 - 675 WP_143978105.1 IS6 family transposase -
FOC61_RS10780 2201673..2201798 - 126 WP_002456301.1 ATP-binding cassette domain-containing protein -
FOC61_RS10785 2202292..2202480 + 189 WP_074839874.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10510.19 Da        Isoelectric Point: 10.1215

>T158362 WP_002452576.1 NZ_CP053957:c2197496-2197230 [Staphylococcus capitis]
MNKYNVTFTPTAFEDYKYWQTQDKKLLKKINSLIKSIQRNGILEGEGKPEPLKGNLKGYYSRRMNHEHRLVYTIKDPSII
IIACRYHY

Download         Length: 267 bp

>T158362 NZ_CP069627:3442279-3442566 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9651.68 Da        Isoelectric Point: 4.1237

>AT158362 WP_002452575.1 NZ_CP053957:c2197743-2197489 [Staphylococcus capitis]
MTVLTYSNARKDFRKLIDKVNDDSDTVTITTNDRNAVLISEDDYNSIMETLYLQQSPVNAKRLAQSMEEAERVNTVEVDI
TTYE

Download         Length: 255 bp

>AT158362 NZ_CP069627:3442553-3442855 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U9TK67

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5RQB4

References