Detailed information of TA system TA158361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2183334..2183857
• Replicon: chromosome
• Accession: NZ_CP053957
• Organism: Staphylococcus capitis strain FDAARGOS_753

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: C5QR05
• Locus tag: FOC61_RS10660
• Protein ID: WP_002441971.1
• Coordinates: 2183591..2183857 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: C5QR06
• Locus tag: FOC61_RS10655
• Protein ID: WP_002441972.1
• Coordinates: 2183334..2183591 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC61_RS10620	2178565..2178943	+	379	Protein_2059	transposase	-
FOC61_RS10625	2179988..2180263	-	276	WP_039973716.1	helix-turn-helix domain-containing protein	-
FOC61_RS10630	2180247..2180435	-	189	Protein_2061	type II toxin-antitoxin system RelE/ParE family toxin	-
FOC61_RS10635	2180521..2181664	-	1144	Protein_2062	IS200/IS605 family element transposase accessory protein TnpB	-
FOC61_RS10640	2181734..2181871	-	138	WP_165766553.1	hypothetical protein	-
FOC61_RS10645	2182562..2182741	+	180	WP_001832816.1	CsbD family protein	-
FOC61_RS10650	2182774..2183172	-	399	WP_039973715.1	YolD-like family protein	-
FOC61_RS10655	2183334..2183591	+	258	WP_002441972.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FOC61_RS10660	2183591..2183857	+	267	WP_002441971.1	Txe/YoeB family addiction module toxin	Toxin
FOC61_RS10665	2183874..2184044	+	171	WP_016898857.1	hypothetical protein	-
FOC61_RS10670	2184391..2184663	+	273	WP_039973713.1	hypothetical protein	-
FOC61_RS10675	2184783..2185178	-	396	WP_016898839.1	arsenate reductase (thioredoxin)	-
FOC61_RS10680	2185195..2186487	-	1293	WP_039973710.1	arsenite efflux transporter membrane subunit ArsB	-
FOC61_RS10685	2186487..2186801	-	315	WP_002452589.1	metalloregulator ArsR/SmtB family transcription factor	-
FOC61_RS10690	2186798..2188462	-	1665	WP_039973709.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10692.34 Da
• Isoelectric Point: 10.2282

>T158361 WP_002441971.1 NZ_CP053957:2183591-2183857 [Staphylococcus capitis]
MAKYKINIKNSAKTDLKKIKRSHLQEQFLKIVEILKYDPYQQSQSFEKLHPKHLGRYSRRINHQHRVVYTIDEENKEVLI
LAAWSHYE

Nucleotide

• Length: 267 bp

>T158361 NZ_CP069627:3360416-3360793 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10041.10 Da
• Isoelectric Point: 4.5610

>AT158361 WP_002441972.1 NZ_CP053957:2183334-2183591 [Staphylococcus capitis]
MKSKTPTEARKDFYQLLKRVNNDHEPVYIEGKYDESNAVIIGMEDWRSINETIYLEATGTMDKVREREHDNSGYTNIDDI
DWARL

Nucleotide

• Length: 258 bp

>AT158361 NZ_CP069627:3359958-3360326 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A8B5RUG0