158352

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 303664..304183 Replicon chromosome
Accession NZ_CP053957
Organism Staphylococcus capitis strain FDAARGOS_753

Toxin (Protein)


Gene name yoeB Uniprot ID A0A507SVT5
Locus tag FOC61_RS01365 Protein ID WP_002436254.1
Coordinates 303664..303933 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1J4EAU6
Locus tag FOC61_RS01370 Protein ID WP_002436168.1
Coordinates 303926..304183 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC61_RS01350 300719..301477 + 759 WP_002454143.1 esterase family protein -
FOC61_RS01355 301943..303091 + 1149 Protein_267 CapA family protein -
FOC61_RS01360 303155..303520 - 366 WP_002454140.1 DUF4870 domain-containing protein -
FOC61_RS01365 303664..303933 - 270 WP_002436254.1 Txe/YoeB family addiction module toxin Toxin
FOC61_RS01370 303926..304183 - 258 WP_002436168.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOC61_RS01375 304368..305225 + 858 WP_002454139.1 ABC transporter substrate-binding protein -
FOC61_RS01380 305340..306980 - 1641 WP_002454138.1 alpha-keto acid decarboxylase family protein -
FOC61_RS01385 307153..307608 + 456 WP_002454137.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC61_RS01390 307981..308730 + 750 WP_029625748.1 hypothetical protein -
FOC61_RS01395 308625..308882 - 258 WP_016898538.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10524.00 Da        Isoelectric Point: 9.7885

>T158352 WP_002436254.1 NZ_CP053957:c303933-303664 [Staphylococcus capitis]
MSKFSVTFTAQAFKDYQYWQQHNQNYFKKVNALLKSIARDGCVDGIGKPEALKGNYEGYFSRRVSIEHRLIYKIKDDSIF
VVSCRFHYQ

Download         Length: 270 bp

>T158352 NZ_CP069627:c739442-739188 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9737.79 Da        Isoelectric Point: 4.1359

>AT158352 WP_002436168.1 NZ_CP053957:c304183-303926 [Staphylococcus capitis]
MPSVNYSNARQNFKELITKVNEDSVAYTITTKENENAVILAEKDYNAMLETMYLQSNLANVSHLNQSIMELNHNQTITIE
IDDNE

Download         Length: 258 bp

>AT158352 NZ_CP069627:c739690-739439 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A507SVT5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4EAU6

References