Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 589985..590570 Replicon chromosome
Accession NZ_CP053947
Organism Acinetobacter sp. WY4

Toxin (Protein)


Gene name higB Uniprot ID N9CJF7
Locus tag G4D73_RS02705 Protein ID WP_000897307.1
Coordinates 589985..590305 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G4D73_RS02710 Protein ID WP_000369781.1
Coordinates 590298..590570 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4D73_RS02690 586140..587336 - 1197 WP_005251952.1 PilT/PilU family type 4a pilus ATPase -
G4D73_RS02695 587932..589119 - 1188 WP_087551687.1 Tet(A)/Tet(B)/Tet(C) family tetracycline efflux MFS transporter -
G4D73_RS02700 589185..589826 + 642 WP_004787586.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
G4D73_RS02705 589985..590305 + 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G4D73_RS02710 590298..590570 + 273 WP_000369781.1 NadS family protein Antitoxin
G4D73_RS02715 591063..592538 + 1476 WP_000052512.1 ABC-F type ribosomal protection protein Msr(E) -
G4D73_RS02720 592594..593478 + 885 WP_000155092.1 Mph(E) family macrolide 2'-phosphotransferase -
G4D73_RS02725 593668..594279 - 612 WP_015060246.1 recombinase family protein -
G4D73_RS02730 594480..594755 + 276 WP_004967304.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IS/Tn tet(39) / msr(E) / mph(E) - 587932..596235 8303


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12187.95 Da        Isoelectric Point: 7.1639

>T158341 WP_000897307.1 NZ_CP053947:589985-590305 [Acinetobacter sp. WY4]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG

Download         Length: 321 bp

>T158341 NZ_CP069624:c3510894-3510742 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10149.61 Da        Isoelectric Point: 8.6582

>AT158341 WP_000369781.1 NZ_CP053947:590298-590570 [Acinetobacter sp. WY4]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT158341 NZ_CP069624:3510943-3511000 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8TMZ3

Antitoxin

Source ID Structure

References