Detailed information of TA system TA158330

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 171450..172104
• Replicon: chromosome
• Accession: NZ_CP053929
• Organism: Pseudomonas sp. B14-6

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HP062_RS00715
• Protein ID: WP_083377329.1
• Coordinates: 171754..172104 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A024E6Q4
• Locus tag: HP062_RS00710
• Protein ID: WP_010458842.1
• Coordinates: 171450..171764 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP062_RS00695	169170..169370	+	201	WP_010458836.1	hypothetical protein	-
HP062_RS00700	169450..169781	+	332	Protein_135	DUF2790 domain-containing protein	-
HP062_RS00705	169950..171275	-	1326	WP_077748738.1	OprD family porin	-
HP062_RS00710	171450..171764	-	315	WP_010458842.1	XRE family transcriptional regulator	Antitoxin
HP062_RS00715	171754..172104	-	351	WP_083377329.1	toxin	Toxin
HP062_RS00720	172393..173856	-	1464	WP_010458846.1	NADH-quinone oxidoreductase subunit NuoN	-
HP062_RS00725	173864..175396	-	1533	WP_010458848.1	NADH-quinone oxidoreductase subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13847.59 Da
• Isoelectric Point: 7.1657

>T158330 WP_083377329.1 NZ_CP053929:c172104-171754 [Pseudomonas sp. B14-6]
MDALFIELRMFQKHRDEYLDDDLFRSFQLELLKNPEAGDLIEGTGGLRKIRFCDQRRGKGKRGGLRVIYYGWSGFDQFWL
FTVYSKNEQDDLSPSQKNIFRQALDREINTRSHYET

Nucleotide

• Length: 351 bp

>T158330 NZ_CP069624:c739442-739188 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11972.96 Da
• Isoelectric Point: 9.9896

>AT158330 WP_010458842.1 NZ_CP053929:c171764-171450 [Pseudomonas sp. B14-6]
MKRDIFSELMDGLEALAEERQGKITLRTHKVQLPKLMPITAEEVVAIRQQLNLSRPVFAMYLRTNTRTLENWEQGRAIPN
AQATTLIRLVERFPQTIEQLAALT

Nucleotide

• Length: 315 bp

>AT158330 NZ_CP069624:c739690-739439 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A024E6Q4