Detailed information of TA system TA158320

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3469891..3470551
• Replicon: chromosome
• Accession: NZ_CP053927
• Organism: Serratia marcescens strain 11/2010

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HP437_RS17525
• Protein ID: WP_180547475.1
• Coordinates: 3470198..3470551 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A177IM12
• Locus tag: HP437_RS17520
• Protein ID: WP_049200011.1
• Coordinates: 3469891..3470193 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP437_RS17495	3464961..3465836	-	876	WP_180547473.1	ATP-binding cassette domain-containing protein	-
HP437_RS17500	3465833..3467119	-	1287	WP_180547474.1	high-affinity branched-chain amino acid ABC transporter permease LivM	-
HP437_RS17505	3467130..3468044	-	915	WP_004928592.1	branched-chain amino acid ABC transporter permease	-
HP437_RS17510	3468170..3469288	-	1119	WP_087763177.1	branched-chain amino acid ABC transporter substrate-binding protein	-
HP437_RS17520	3469891..3470193	-	303	WP_049200011.1	XRE family transcriptional regulator	Antitoxin
HP437_RS17525	3470198..3470551	-	354	WP_180547475.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HP437_RS17530	3470871..3471236	-	366	WP_180547476.1	diacylglycerol kinase	-
HP437_RS17535	3471455..3472579	-	1125	WP_060420308.1	DNA-binding protein	-
HP437_RS17540	3473319..3475058	+	1740	WP_172906261.1	fatty acyl-AMP ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-79)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13170.04 Da
• Isoelectric Point: 9.5349

>T158320 WP_180547475.1 NZ_CP053927:c3470551-3470198 [Serratia marcescens]
VWGIKTTDAFDDGFSSLNDADRAGVLAALMVLRERGSGLPRPYAATVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMLQIADRAFTCWLNTLNEKE

Nucleotide

• Length: 354 bp

>T158320 NZ_CP069621:3547829-3548143 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11017.82 Da
• Isoelectric Point: 5.7316

>AT158320 WP_049200011.1 NZ_CP053927:c3470193-3469891 [Serratia marcescens]
MGRTLEQLIADEKPEVVANAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEVVL

Nucleotide

• Length: 303 bp

>AT158320 NZ_CP069621:3547593-3547826 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Antitoxin

• AlphaFold DB: A0A177IM12