Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3641936..3642596 Replicon chromosome
Accession NZ_CP053925
Organism Serratia marcescens strain 12/2010

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BYZ0
Locus tag HP475_RS17900 Protein ID WP_041035904.1
Coordinates 3642243..3642596 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag HP475_RS17895 Protein ID WP_033635213.1
Coordinates 3641936..3642238 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP475_RS17875 3637558..3638472 - 915 WP_004928592.1 branched-chain amino acid ABC transporter permease -
HP475_RS17880 3638598..3639716 - 1119 WP_033647954.1 branched-chain amino acid ABC transporter substrate-binding protein -
HP475_RS17890 3640320..3641528 - 1209 WP_049235464.1 aldose 1-epimerase family protein -
HP475_RS17895 3641936..3642238 - 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
HP475_RS17900 3642243..3642596 - 354 WP_041035904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HP475_RS17905 3643036..3644331 + 1296 WP_049235463.1 MFS transporter -
HP475_RS17910 3644359..3645165 + 807 WP_049235462.1 substrate-binding domain-containing protein -
HP475_RS17915 3645140..3646039 - 900 WP_039565149.1 LysR family transcriptional regulator -
HP475_RS17920 3646132..3646497 - 366 WP_033635218.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13446.27 Da        Isoelectric Point: 8.9000

>T158298 WP_041035904.1 NZ_CP053925:c3642596-3642243 [Serratia marcescens]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQAADREFTNWLNTLNEKE

Download         Length: 354 bp

>T158298 NZ_CP069605:1578334-1578648 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACTGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTAAATCGCCGGATAGTGATCCCGTTGCTCCCGGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGTAAAGAATACGCCGTAATGGCGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTCTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT158298 WP_033635213.1 NZ_CP053925:c3642238-3641936 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT158298 NZ_CP069605:1578095-1578331 [Dickeya dianthicola]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGCTCCGGGCGCGTGAAGCGGG
TATTAACCTGAGTGCCACCCTGACAACCGCCCTGGATGCAGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACCGGGAAGCCATCGACGCATTAAACCGTTTTCATGATGAAAACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BYZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References