Detailed information of TA system TA158267

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3978434..3979029
• Replicon: chromosome
• Accession: NZ_CP053917
• Organism: Pseudomonas aeruginosa strain PSE6684

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A9E8L6K5
• Locus tag: HPT07_RS18700
• Protein ID: WP_071534386.1
• Coordinates: 3978434..3978712 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HPT07_RS18705
• Protein ID: WP_003133769.1
• Coordinates: 3978724..3979029 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPT07_RS18685	3973866..3975104	+	1239	WP_033938412.1	C69 family dipeptidase	-
HPT07_RS18690	3975166..3975813	+	648	WP_003095021.1	carbonate dehydratase	-
HPT07_RS18695	3975883..3978111	-	2229	WP_033938414.1	TonB-dependent receptor	-
HPT07_RS18700	3978434..3978712	+	279	WP_071534386.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPT07_RS18705	3978724..3979029	+	306	WP_003133769.1	HigA family addiction module antidote protein	Antitoxin
HPT07_RS18710	3979365..3979955	+	591	WP_108703096.1	ankyrin repeat domain-containing protein	-
HPT07_RS18715	3980362..3982569	+	2208	WP_079381482.1	DEAD/DEAH box helicase	-
HPT07_RS18720	3982566..3983240	+	675	WP_079381483.1	DUF2290 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-82)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10698.23 Da
• Isoelectric Point: 7.9184

>T158267 WP_071534386.1 NZ_CP053917:3978434-3978712 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMHHAATELRDLRSPPGNRLEPLQGKRVGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Nucleotide

• Length: 279 bp

>T158267 NZ_CP069602:1862994-1863308 [Dickeya dianthicola]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTACCCGGCAGGCCGCCGGCCGGATCGCCTAGTCC
CTGTCGTCAGGCTGACGGACGGCAAAGAGTACGCCGTAATGACGCACGAGCTGGCAAGTATCCCTGTGCAGGCTCTGGGG
GCGGTGTTTTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGTATTTAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11214.73 Da
• Isoelectric Point: 4.6081

>AT158267 WP_003133769.1 NZ_CP053917:3978724-3979029 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Nucleotide

• Length: 306 bp

>AT158267 NZ_CP069602:1862755-1862991 [Dickeya dianthicola]
ATGACCGCGAAACAGCGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGGTCCGGGCGCGTGAGGCGGG
CATTAACCTGAGTGCCACTCTGACAACCGCCCTGGATGCCGAGCTTCGCCGTCATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAATCGTTTTCATGATGAGCACGGCTGTTTCAGCGATGAATACCGGACGTTTTAA