158211

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 740696..741471 Replicon chromosome
Accession NZ_CP053875
Organism Klebsiella pneumoniae strain KPN142

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag HPY03_RS03710 Protein ID WP_004150910.1
Coordinates 740986..741471 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag HPY03_RS03705 Protein ID WP_004150912.1
Coordinates 740696..740989 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY03_RS03685 (HPY03_03680) 735904..736506 - 603 WP_062954968.1 short chain dehydrogenase -
HPY03_RS03690 (HPY03_03685) 736604..737515 + 912 WP_004188550.1 LysR family transcriptional regulator -
HPY03_RS03695 (HPY03_03690) 737516..738664 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
HPY03_RS03700 (HPY03_03695) 738675..740051 - 1377 WP_004217775.1 cystathionine beta-synthase -
HPY03_RS03705 (HPY03_03700) 740696..740989 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
HPY03_RS03710 (HPY03_03705) 740986..741471 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
HPY03_RS03715 (HPY03_03710) 742175..742768 + 594 WP_004188553.1 hypothetical protein -
HPY03_RS03720 (HPY03_03715) 742865..743081 + 217 Protein_731 transposase -
HPY03_RS03725 (HPY03_03720) 743687..744559 + 873 WP_004188557.1 ParA family protein -
HPY03_RS03730 (HPY03_03725) 744559..744942 + 384 WP_004150906.1 hypothetical protein -
HPY03_RS03735 (HPY03_03730) 744935..746302 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 742865..743017 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T158211 WP_004150910.1 NZ_CP053875:740986-741471 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T158211 NZ_CP069597:1628439-1628696 [Dickeya dianthicola]
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCATGT
GCATGTTTGTTATGGCCATCATGAACTTATCATCAGTATTCGTACCGGAATCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGTGCATATCCGGGCCCACCGCCAACAGCTGTTGAGCATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCGGGAAAACTGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT158211 WP_004150912.1 NZ_CP053875:740696-740989 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT158211 NZ_CP069597:1628704-1629192 [Dickeya dianthicola]
ATGCATAAAATTGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGAAGATGGTCTGGTTTGCGACAT
CAATCTTTATCACTATGCCCCCAGCCCGGTATTTTCGAACGCCAGCCAATTTATCAAGTTTGGGTTGCTGCCGGATGGCT
CGCTGGAATGGCTGCCGGATATTAAGCTTTCCGCGTCTGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGCGAGAACGGAACTTCGCTGATGTCATCTCTCGCGCTTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATTGCGGTGGAGAAATACGGTAACAGCACGGTGGCGAAAAAAGCGGGGGCGAAAAGCCGCACCAGTC
TGTATAAGTCGCTGAATAAGAATACCCATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References