Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 113339..114066 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP053863 | ||
| Organism | Klebsiella pneumoniae strain KP-Zhen | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | GWF98_RS26570 | Protein ID | WP_011251285.1 |
| Coordinates | 113339..113650 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | GWF98_RS26575 | Protein ID | WP_011251286.1 |
| Coordinates | 113647..114066 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GWF98_RS26530 (GWF98_26515) | 108405..108860 | - | 456 | WP_235143851.1 | hypothetical protein | - |
| GWF98_RS26535 (GWF98_26520) | 109023..109598 | - | 576 | WP_074424927.1 | hypothetical protein | - |
| GWF98_RS26540 (GWF98_26525) | 109715..110671 | - | 957 | WP_011251280.1 | DsbA family protein | - |
| GWF98_RS26545 (GWF98_26530) | 110731..111072 | - | 342 | WP_011251281.1 | hypothetical protein | - |
| GWF98_RS26550 (GWF98_26535) | 111086..111397 | - | 312 | WP_011251282.1 | hypothetical protein | - |
| GWF98_RS26555 (GWF98_26540) | 111414..111863 | - | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| GWF98_RS26565 (GWF98_26550) | 112697..113134 | + | 438 | Protein_129 | DDE-type integrase/transposase/recombinase | - |
| GWF98_RS26570 (GWF98_26555) | 113339..113650 | + | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| GWF98_RS26575 (GWF98_26560) | 113647..114066 | + | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| GWF98_RS26580 (GWF98_26565) | 114213..115181 | + | 969 | WP_074428168.1 | IS5 family transposase | - |
| GWF98_RS26585 (GWF98_26570) | 115241..115354 | - | 114 | Protein_133 | Hha/YmoA family nucleoid-associated regulatory protein | - |
| GWF98_RS26590 (GWF98_26575) | 115415..115909 | - | 495 | WP_004213594.1 | hypothetical protein | - |
| GWF98_RS26595 (GWF98_26580) | 115951..118920 | - | 2970 | WP_004213592.1 | Tn3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA / iroN / iroD / iroC / iroB | 1..222711 | 222711 | |
| - | inside | IScluster/Tn | - | - | 111865..119480 | 7615 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T158200 WP_011251285.1 NZ_CP053863:113339-113650 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
>T158200 NZ_CP069596:1628439-1628696 [Dickeya dianthicola]
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCATGT
GCATGTTTGTTATGGCCATCATGAACTTATCATCAGTATTCGTACCGGAATCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGTGCATATCCGGGCCCACCGCCAACAGCTGTTGAGCATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCGGGAAAACTGTGA
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCATGT
GCATGTTTGTTATGGCCATCATGAACTTATCATCAGTATTCGTACCGGAATCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGTGCATATCCGGGCCCACCGCCAACAGCTGTTGAGCATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCGGGAAAACTGTGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT158200 WP_011251286.1 NZ_CP053863:113647-114066 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT158200 NZ_CP069596:1628704-1629192 [Dickeya dianthicola]
ATGCATAAAATTGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGAAGATGGTCTGGTTTGCGACAT
CAATCTTTATCACTATGCCCCCAGCCCGGTATTTTCGAACGCCAGCCAATTTATCAAGTTTGGGTTGCTGCCGGATGGCT
CGCTGGAATGGCTGCCGGATATTAAGCTTTCCGCGTCTGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGCGAGAACGGAACTTCGCTGATGTCATCTCTCGCGCTTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATTGCGGTGGAGAAATACGGTAACAGCACGGTGGCGAAAAAAGCGGGGGCGAAAAGCCGCACCAGTC
TGTATAAGTCGCTGAATAAGAATACCCATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAG
ATGCATAAAATTGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGAAGATGGTCTGGTTTGCGACAT
CAATCTTTATCACTATGCCCCCAGCCCGGTATTTTCGAACGCCAGCCAATTTATCAAGTTTGGGTTGCTGCCGGATGGCT
CGCTGGAATGGCTGCCGGATATTAAGCTTTCCGCGTCTGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGCGAGAACGGAACTTCGCTGATGTCATCTCTCGCGCTTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATTGCGGTGGAGAAATACGGTAACAGCACGGTGGCGAAAAAAGCGGGGGCGAAAAGCCGCACCAGTC
TGTATAAGTCGCTGAATAAGAATACCCATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|