Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 731920..732695 Replicon chromosome
Accession NZ_CP053862
Organism Klebsiella pneumoniae strain KP-Zhen

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag GWF98_RS03620 Protein ID WP_004889762.1
Coordinates 732210..732695 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag GWF98_RS03615 Protein ID WP_004150912.1
Coordinates 731920..732213 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWF98_RS03595 (727129) 727129..727731 - 603 WP_002916735.1 short chain dehydrogenase -
GWF98_RS03600 (727829) 727829..728740 + 912 WP_014906929.1 LysR family transcriptional regulator -
GWF98_RS03605 (728741) 728741..729889 - 1149 WP_014906930.1 PLP-dependent aspartate aminotransferase family protein -
GWF98_RS03610 (729900) 729900..731276 - 1377 WP_014906931.1 pyridoxal-phosphate dependent enzyme -
GWF98_RS03615 (731920) 731920..732213 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
GWF98_RS03620 (732210) 732210..732695 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
GWF98_RS03625 (733399) 733399..733992 + 594 WP_004188553.1 hypothetical protein -
GWF98_RS03630 (734089) 734089..734305 + 217 Protein_714 transposase -
GWF98_RS03640 (734983) 734983..735696 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 734089..734241 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T158183 WP_004889762.1 NZ_CP053862:732210-732695 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

>T158183 NZ_CP069595:733246-733677 [Dickeya dianthicola]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGCTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCGCCCTGGTCGGACGGCTATGCGCCGCTGTGGTTGGGCCTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGTTCGGCGCCCGTGGGTAATGCGCAACGGCGTGTTGCTGTCATTGCGGGCAACGAATGGCAAAGGGCA
TCAGCGCTTGTGGCTGGCGTCAGACAGTATGGGTAACGAAGAATGGCGGCTGTTGCGCCAACTGTTGCAGCAGCATCCGT
TGCAGGGAACCGAATCCTCCCGCCATCATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT158183 WP_004150912.1 NZ_CP053862:731920-732213 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT158183 NZ_CP069595:732999-733265 [Dickeya dianthicola]
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAATATGACACGCTGAGCGACGACGACAAGCTGCACTTCATTCGTCTGCTGCAGTGCGATGATCCCGACT
TGTTCAACTGGCTGATGAATCATGGCGAGCCGGTAGATCCGGCGCTGAAACGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References